Figure 1
HB-19 inhibits significantly spontaneous melanoma development. RET mice were treated with HB-19 according to the schedule indicated in Methods and diagnosed frequently over a period of 300 days. A/B. HB-19 treatment delays significantly the onset of small cutaneous tumors (≥ 4 mm2) in panel A and of huge cutaneous tumors (> 60 mm2) in panel B (Log-rank Wilcoxon test, p < 0.001 for both graphs). The dotted lines correspond to data from untreated mice (n = 11) and full lines correspond to HB-19 treated mice (n = 9). C/D. HB-19 treatment significantly delays the incidence of facial (C) and dorsal (D) cutaneous nodules in RET mice. The dotted lines correspond to data from untreated mice and full lines correspond to HB-19 treated mice (Log-rank Wilcoxon test, p < 0.001). E/F. Number of facial (E) and dorsal (F) cutaneous nodules during the period of 120 days. The histograms show the progression of the number of nodules (calculated for 10 mice) in untreated (hatched bars) and HB-19 treated (black bars) mice, respectively. HB-19 treated mice displayed less cutaneous nodules than untreated mice (p < 0.05 for both graphs).