Figure 6From: Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma Immunohistochemical detection of p16 in a liver metastasis. Liver metastasis of a moderately differentiated colorectal cancer with strong cytoplasmic and also nuclear expression of p16 in tumor cells. Non-neoplastic liver tissue adjacent to colorectal cancer metastasis is completely devoid of p16 expression. Anti-p16-antibody. Hematoxylin-counterstain.Back to article page