Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

BMC Cancer

Table 1 Loci that have been identified as significant determinants of prostate cancer risk in four independent genome wide association studies.

Gene	Location	Marker	MAF	Post replication P value	Position within gene	Source
HNF1B	17q21.3	rs4430796 rs11649743	0.479 0.479	9.58 × 10-¹⁰ 1.7 × 10^-9	IVS2 IVS4	[7, 8, 34]
MSMB	10q11.2	rs10993994	0.339	8.7 × 10^-29 7.31 × 10^-13	5' UTR	[8, 9]
LMTK2	17q25.3	rs6465657	0.438	1.1 × 10^-9	IVS9	[9]
SLC22A3	6q26-q27	rs9364554	0.233	5.5 × 10^-10	IVS5	[9]
CTBP2	10q26.13	rs4962416	0.229	1.70 × 10^-7	IVS1	[8]
MYEOV	11q13	rs10896449	0.492	1.76 × 10^-9	Intergenic, 5' to gene	[8]
JAZF1	7p15.2-p15.1	rs10486567	0.267	2.14 × 10^-6	IVS2	[8]

ISSN: 1471-2407