|
Genotype
|
Predicted phenotypes
|
(n)
|
% of total
|
Age (median)
|
Genotypes
|
(n)
|
Genotype frequency
|
|---|
|
CYP2C191
|
*2/*2
|
(4)
|
4.4
|
63
|
*2/*2
|
(4)
|
0.03
|
| |
*1/*2
|
(15)
|
16.7
|
66
|
*1/*2
|
(15)
|
0.21
|
| |
*1/*1
|
(35)
|
38.9
|
62
|
*1/*1
|
(35)
|
0.35
|
| |
*1/*17 and *2/*17
|
(33)
|
36.7
|
62
|
*1/*17
|
(24)
|
0.27
|
| | | | | |
*2/*17
|
(9)
|
0.08
|
| |
*17/*17
|
(3)
|
3.3
|
65
|
*17/*17
|
(3)
|
0.05
|
|
CYP2D62
|
PM
|
(6)
|
6.7
|
65
|
*4/*4
|
(4)
|
0.04
|
| | | | | |
*4/*5
|
(2)
|
0.01
|
| |
IM
|
(32)
|
35.5
|
55
|
*1/*3
|
(1)
|
0.01
|
| | | | | |
*1/*4
|
(27)
|
0.29
|
| | | | | |
*1/*5
|
(3)
|
0.04
|
| | | | | |
*1/*6
|
(1)
|
0.01
|
| |
Wt/Wt
|
(51)
|
56.7
|
60
|
*1/*1
|
(51)
|
0.48
|
| |
UM
|
(1)
|
1.1
|
50
|
*1/*2 ×2
|
(1)
| |
|
CYP3A5
|
Vt/Vt
|
(76)
|
84.4
|
60
|
*3/*3
|
(76)
|
0.85
|
| |
Wt/Vt
|
(14)
|
15.6
|
73
|
*1/*3
|
(14)
|
0.50
|
| |
Wt/Wt
|
(0)
| | |
*1/*1
|
(0)
| |
|
SULT1A1
|
Vt/Vt
|
(14)
|
15.6
|
61
|
*2/*2
|
(14)
|
0.11
|
| |
Wt/Vt
|
(32)
|
35.5
|
59
|
*1/*2
|
(32)
|
0.44
|
| |
Wt/Wt
|
(44)
|
48.9
|
59
|
*1/*1
|
(44)
|
0.45
|
|
SULT1A1 copy numbers
|
1
|
(3)
|
3.3
|
59
| | | |
| |
2
|
(59)
|
65.6
|
60
| | | |
| |
3
|
(21)
|
23.3
|
67
| | | |
| |
4
|
(5)
|
5.6
|
72
| | | |
| |
5
|
(2)
|
2.2
|
69
| | | |
-
1*2/*2, subjects homozygous for the variant allele CYP2C19*2; *1/*2, subjects heterozygous for the variant allele CYP2C19*2; intermediate metabolizer, subjects homozygous for the wild type allele CYP2C19*1 and with CYP2C19*2/*17; *1/*17 subjects heterozygous for the CYP2C19*17 variant allele; *17/*17 Vt*17 subjects homozygous for the CYP2C19*17 variant allele
-
2PM, poor metabolizer CYP2D6; IM, intermediate metabolizer wild type/variant type CYP2D6; Wt/Wt, wild type/wild type CYP2D6; UM, ultra rapid metabolizer CYP2D6.
