Table 2 CYP2C19, CYP2D6, CYP3A5, AND SULT1A1 genotype frequencies
Genotype | Predicted phenotypes | (n) | % of total | Age (median) | Genotypes | (n) | Genotype frequency |
|---|---|---|---|---|---|---|---|
CYP2C191 | *2/*2 | (4) | 4.4 | 63 | *2/*2 | (4) | 0.03 |
*1/*2 | (15) | 16.7 | 66 | *1/*2 | (15) | 0.21 | |
*1/*1 | (35) | 38.9 | 62 | *1/*1 | (35) | 0.35 | |
*1/*17 and *2/*17 | (33) | 36.7 | 62 | *1/*17 | (24) | 0.27 | |
*2/*17 | (9) | 0.08 | |||||
*17/*17 | (3) | 3.3 | 65 | *17/*17 | (3) | 0.05 | |
CYP2D62 | PM | (6) | 6.7 | 65 | *4/*4 | (4) | 0.04 |
*4/*5 | (2) | 0.01 | |||||
IM | (32) | 35.5 | 55 | *1/*3 | (1) | 0.01 | |
*1/*4 | (27) | 0.29 | |||||
*1/*5 | (3) | 0.04 | |||||
*1/*6 | (1) | 0.01 | |||||
Wt/Wt | (51) | 56.7 | 60 | *1/*1 | (51) | 0.48 | |
UM | (1) | 1.1 | 50 | *1/*2 ×2 | (1) | ||
CYP3A5 | Vt/Vt | (76) | 84.4 | 60 | *3/*3 | (76) | 0.85 |
Wt/Vt | (14) | 15.6 | 73 | *1/*3 | (14) | 0.50 | |
Wt/Wt | (0) | *1/*1 | (0) | ||||
SULT1A1 | Vt/Vt | (14) | 15.6 | 61 | *2/*2 | (14) | 0.11 |
Wt/Vt | (32) | 35.5 | 59 | *1/*2 | (32) | 0.44 | |
Wt/Wt | (44) | 48.9 | 59 | *1/*1 | (44) | 0.45 | |
SULT1A1 copy numbers | 1 | (3) | 3.3 | 59 | |||
2 | (59) | 65.6 | 60 | ||||
3 | (21) | 23.3 | 67 | ||||
4 | (5) | 5.6 | 72 | ||||
5 | (2) | 2.2 | 69 |