Figure 1From: Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer Schematic representation of (A) tamoxifen and (B) estradiol metabolism and the enzymes involved. 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-dedimethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N -oxide; CYP, cytochrome P450; SULT, sulfotransferase; UGT, Uridine 5'-diphospho-glucuronosyltransferase; E2, estradiol; E1, estrone; E1S, estrone sulphate; 4OHE2, 4-hydroxyE2; 2OHE2, 2-hydroxyE2; 4MeOE2, 4-methoxyE2; 2MeOE2, 2-methoxyE2; 4OHE1, 4-hydroxyE1; 2OHE1, 2-hydroxyE1; 4MeOE1, 4-methoxyE1; 2MeOE1, 2-methoxyE1; 16αOHE1, 16α-hydroxyE1; Catechol-O-methyl transferase, COMT. Bolded texts indicate tamoxifen and estrogen metabolizing enzymes investigated.Back to article page