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Table 3 Copy number changes of TP53 and MYC and p53 immunoreactivity in the samples tested for mutation analyses

From: Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?

Case No.

MYC

TP53

Mutation of TP53exons 5-8

Mutant allele

MDM2

p53 IHC

M3

-

+

wt

 

-

-

M4

-

+

wt

 

ns

-

M5

-

+

wt

 

ns

+

M6

-

+

wt

 

-

+

M7

ns

+

wt

 

-

+

M8

-

+

wt

 

ns

-

M9

-

+

wt

 

ns

+

M10

-

+

wt

 

-

+

M11

ns

-

wt

 

ns

-

M12

+

-

Exons 5/8

hemi/hetero

ns

+

M13

+

-

NA

 

ns

-

S1m

-

+

wt

 

-

+

S1i

-

+

wt

 

-

+

S2m

-

+

wt

 

-

+

S2i

ns

+

exon 7

hemi

ns

+

S3m

ns

ns

exon 8

hemi

ns

+

S3i

+

-

exons 5/6/8

hemi

ns

+

A1m

-

+

wt

 

-

null

A1i

+

-

NA

 

-

null

A2m

-

+

wt

 

ns

+

A2i

+

-

exon 8

hemi

ns

+

A3m

-

+

wt

 

ns

+

A3i

-

-

exon 5

hemi

-

+

A4m

-

+

wt

 

-

null

A4i

ns

ns

exon 5

hemi

ns

null

A8m

ns

+

wt

 

-

null

A8i

+

-

NA

 

ns

null

A9m

-

+

wt

 

-

+

A9i

+

+

exon 6

hemi

ns

+

  1. ns = not significant; wt = wild type; NA = not assessable; hemi = hemizygous; hetero = heterozygous.
  2. M12, exon 5: R175H (CGC > CAC), C182C (TGC > TGT), S183L (TCA > TTA); exon 8: R267R (CGG > CGA)
  3. S2i, exon 7: C242F (TGC > TTC)
  4. S3m, exon 8: R273S (CGT > AGT)
  5. S3i, exon 5: A161V (GCC > GTC); exon 6: T211I (ACT > ATT); exon 8: R273S (CGT > AGT)
  6. A2i, exon 8: R273 H (CGT > CAT)
  7. A3i, exon 5: A161T (GCC > ACC)
  8. A4i, exon 5: IVS5+1G > T
  9. A9i, exon 6: Y220C (TAT > TGT)