Table 2 HR for death in intention-to-treat population (n = 567)--univariable and multivariable analyses
| Â | Univariable analyses | Multivariable analyses | ||
|---|---|---|---|---|
|  | HR (95% CI) | p* | HR (95% CI) | p†|
Age (years) | Â | 0.033 | Â | 0.335 |
   ≤55 | 1 (Ref) |  | 1 (Ref) |  |
   >55 | 1.231(1.017-1.490) | 0.033 | 1.224(0.982-1.524) | 0.335 |
Sex | Â | 0.816 | Â | 0.960 |
   Women | 1 (Ref) |  | 1 (Ref) |  |
   Men | 1.025(0.833-1.261) | 0.816 | 0.943(0.748-1.188) | 0.960 |
Tumor size | Â | 0.000 | Â | 0.111 |
   ≤5 cm | 1 (Ref) |  | 1 (Ref) |  |
   5-7 cm | 1.527(1.217-1.917) | 0.000 | 1.266(0.991-1.617) | 0.059 |
   >7 cm | 1.728(1.338-2.233) | 0.000 | 1.397(1.005-1.943) | 0.047 |
Tumour site | Â | 0.101 | Â | 0.005 |
   Upper stomach | 1 (Ref) |  | 1 (Ref) |  |
   Middle stomach | 0.624(0.477-0.816) | 0.001 | 0.585(0.436-0.786) | 0.000 |
   Lower stomach | 0.626(0.495-0.792) | 0.000 | 0.634(0.482-0.833) | 0.001 |
   Whole stomach | 1.303(0.889-1.910) | 0.174 | 0.698(0.422-1.154) | 0.161 |
Gross appearance | Â | 0.000 | Â | 0.000 |
   Borrmann types I | 1 (Ref) |  | 1 (Ref) |  |
   Borrmann types II | 1.080(0.824-1.416) | 0.576 | 0.979(0.740-1.294) | 0.879 |
   Borrmann types III | 1.723(1.364-2.175) | 0.000 | 1.601(1.253-2.046) | 0.000 |
   Borrmann types IV | 2.141(1.507-3.044) | 0.000 | 1.282(0.841-1.952) | 0.248 |
Tumour stage | Â | 0.000 | Â | 0.651 |
   T1 | 1 (Ref) |  | 1 (Ref) |  |
   T2 | 0.855(0.638-1.146) | 0.295 | 0.799(0.590-1.082) | 0.146 |
   T3 | 1.262(0.956-1.615) | 0.064 | 0.917(0.698-1.205) | 0.535 |
   T4 | 1.867(1.284-2.716) | 0.001 | 1.005(0.657-1.537) | 0.983 |
Clinical node status | Â | 0.372 | Â | 0.438 |
   Negative | 1 (Ref) |  | 1 (Ref) |  |
   Positive | 1.376(0.683-2.770) | 0.372 | 1.652(0.794-3.436) | 0.438 |
Lymph-node stage | Â | 0.000 | Â | 0.000 |
   N0 | 1 (Ref) |  | 1 (Ref) |  |
   N1 | 1.342(1.082-1.666) | 0.008 | 1.119(0.863-1.450) | 0.397 |
   N2 | 1.480(1.099-1.994) | 0.010 | 1.238(0.889-1.725) | 0.206 |
   N3 | 3.603(2.497-5.199) | 0.000 | 2.653(1.684-4.179) | 0.000 |
Histological type(%) | Â | 0.221 | Â | 0.556 |
   Differentiated | 1 (Ref) |  | 1 (Ref) |  |
   Undifferentiated | 1.177(0.591-1.529) | 0.221 | 0.897(0.624-1.289) | 0.556 |
Joint organ removal | Â | 0.000 | Â | 0.000 |
   None | 1 (Ref) |  | 1 (Ref) |  |
   Pancreas or spleen | 1.964(1.374-2.808) | 0.000 | 1.364(0.902-2.062) | 0.141 |
   Liver or gall | 1.380(0.896-2.125) | 0.144 | 1.291(0.823-2.023) | 0.266 |
   Transverse colon | 1.882(1.321-2.681) | 0.000 | 1.446(0.984-2.125) | 0.060 |
Gastrectomy | Â | 0.000 | Â | 0.001 |
   Total | 1 (Ref) |  | 1 (Ref) |  |
   Subtotal | 0.549(0.422-0.714) | 0.000 | 0.833(0.563-1.233) | 0.001 |
Blood transfusion | Â | 0.356 | Â | 0.580 |
   No | 1 (Ref) |  | 1 (Ref) |  |
   Yes | 1.094(0.904-1.324) | 0.356 | 1.003(0.815-1.234) | 0.580 |
Blood loss | Â | 0.789 | Â | 0.199 |
   ≤200 ml | 1 (Ref) |  | 1 (Ref) |  |
   200-400 ml | 0.901(0.723-1.122) | 0.350 | 0.900(0.715-1.134) | 0.373 |
   >400 ml | 1.049(0.816-1.347) | 0.710 | 0.736(0.552-0.980) | 0.036 |
Lymph node dissection | Â | 0.004 | Â | 0.045 |
   D1 | 1 (Ref) |  | 1 (Ref) |  |
   D2 | 1.019(0.815-1.275) | 0.869 | 1.024(0.801-1.308) | 0.851 |
   D3 | 0.708(0.560-0.894) | 0.004 | 0.771(0.599-0.992) | 0.043 |