Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instability

Table 1 Frameshift mutations in MSI CRCs

Patient number	Stage	Depth of invasion^a	Tumor size	Location^b	MSI	Mutations in mononucleotide repeat tracts
			(mm)			TGFβRII	BAX	hMSH3	hMSH6	IGFIIR	Fas antigen
1	Early	m	4	A	2/6	- ^c	-	NI^d	-	-	-
2	Early	m	4	A	2/8	-	-	NI	-	-	-
3	Early	m	3	S	3/8	-	-	-	-	-	-
4	Early	sm	8	R	3/8	-	-	-	-	-	-
5	Early	sm	14	A	2/5	-	-	NI	-	-	-
6	Early	sm	8	T	3/8	-	-	-	-	-	-
7	Early	sm	4	D	3/10	-	-	-	-	-	-
8	Early	sm	12	NI	2/8	-	-	NI	-	-	-
9	Early	sm	13	R	2/9	-	-	-	-	-	-
10	Late	mp	9	R	2/8	-	De	-	-	-	-
11	Late	mp	20	S	3/9	De ^e	-	De	-	-	-
12	Late	mp	65	A	4/10	-	-	De	De	-	-
13	Late	mp	24	S	2/9	-	-	-	-	-	-

^am, carcinoma tissues were restricted to the mucosa; sm, the deepest carcinoma invasion was in the submucosa; mp, the deepest carcinoma penetration reached the muscularis propria.
^bA, ascending colon; T, transverse colon; D descending colon; S, sigmoid colon; R, rectum.
^c-, wild type.
^dNI, not informative.
^eDe, deletion.

ISSN: 1471-2407