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Table 1 Frameshift mutations in MSI CRCs

From: Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instability

Patient number Stage Depth of invasiona Tumor size Locationb MSI Mutations in mononucleotide repeat tracts
    (mm)    TGFβRII BAX hMSH3 hMSH6 IGFIIR Fas antigen
1 Early m 4 A 2/6 - c - NId - - -
2 Early m 4 A 2/8 - - NI - - -
3 Early m 3 S 3/8 - - - - - -
4 Early sm 8 R 3/8 - - - - - -
5 Early sm 14 A 2/5 - - NI - - -
6 Early sm 8 T 3/8 - - - - - -
7 Early sm 4 D 3/10 - - - - - -
8 Early sm 12 NI 2/8 - - NI - - -
9 Early sm 13 R 2/9 - - - - - -
10 Late mp 9 R 2/8 - De - - - -
11 Late mp 20 S 3/9 De e - De - - -
12 Late mp 65 A 4/10 - - De De - -
13 Late mp 24 S 2/9 - - - - - -
  1. am, carcinoma tissues were restricted to the mucosa; sm, the deepest carcinoma invasion was in the submucosa; mp, the deepest carcinoma penetration reached the muscularis propria.
  2. bA, ascending colon; T, transverse colon; D descending colon; S, sigmoid colon; R, rectum.
  3. c-, wild type.
  4. dNI, not informative.
  5. eDe, deletion.