Table 3 Clinico-epidemiological variables of the 86 colorectal carcinoma patients versus 16 mutant phenotypes of SMAD4 gene
Variable | Total N = 86 | Mutants M = 16 (18.6%) | P value* |
|---|---|---|---|
Age group | |||
≤60 | 52(60.5%) | 11(21.2%) | NS |
>60 | 34(39.5%) | 5(14.7%) | |
Gender | |||
Female | 37 (43.0%) | 7 (18.9%) | NS |
Male | 49 (67.0%) | 9 (18.4%) | |
Dwelling | |||
Rural | 59 (68.6%) | 12 (20.3%) | NS |
Urban | 27 (31.4%) | 4 (14.8%) | |
Tumor location | |||
Colon | 36 (41.9%) | 12 (33.3%) | <0.01 |
Rectum | 50 (58.1%) | 4 (8.0% | |
Nodal status | |||
Involved | 48 (55.8%) | 14 (29.2%) | <0.01 |
Not Involved | 38 (44.2%) | 2 (5.3%) | |
Tumor grade | |||
A + B | 38 (44.2%) | 2 (5.3%) | <0.01 |
C + D | 48 (55.8%) | 14 (29.2%) | |
Smoking status | |||
Ever | 55 (64.0%) | 13 (23.6%) | NS |
Never | 31 (36.0%) | 3 (9.6%) | |
Bleeding PR/Constipation | |||
Yes | 60 (69.8%) | 15 (25.0%) | <0.01 |
No | 26 (30.2%) | 1 (3.8%) | |
Pesticide Exposure | |||
Ever | 53 (61.6%) | 13 (24.5%) | <0.05 |
Never | 33 (38.4%) | 3 (9.1%) | |
KRAS Status | |||
Wild-type | 65 (75.6%) | 5 (7.7%) | < 0.01 |
Mutated | 21 (24.4%) | 11 (52.4%) |