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Table 4 Determinants of overall survival after BCNU treatment of recurrent glioblastoma (n = 34, 30 events)

From: BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors

   Hazard ratio* 95% confidence interval p-value
Age (years) ≤ 53 vs. > 53 (the median) 0.56 0.22-1.45 0.233
Tumor size (mm2) ≤ 736 vs. > 736 (the median) 0.61 0.22-1.71 0.349
  not measurable vs. > 736 0.55 0.18-1.66 0.287
Karnofsky performance score ≤ 70 vs. 80 or 90 1.24 0.50-3.07 0.648
Surgery Complete resection vs. biopsy/partial resection 3.03 1.05-8.74 0.040
Pre-treatment with temozolomide yes vs. no 0.81 0.31-2.13 0.674
Previous relapses 1 vs. more than 1 1.81 0.51-6.48 0.357
  1. *A hazard ratio <1 (>1) indicates an effect in favor of the first (the second) group in terms of progression-free survival.