From: A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates
Parameter | Description | Colorectal Cancer With Specific Gene Targets* | Colorectal Cancer With Pathway Gene Targets** |
---|---|---|---|
k | rate-limiting stages | 5 driver gene mutations | 6 pathway mutations |
m | number of crypts | 15,000,000 | 15,000,000 |
n | stem cells per crypt | 40 | 8 |
u | target mutation rate | 1 × 10-6 per gene per division | 3 × 10-6 per pathway per division |
d | divisions since birth | once every four days | once every four days |
p | probability of cancer | - | - |