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Figure 3 | BMC Cancer

Figure 3

From: A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates

Figure 3

Division rates can be inferred from cancer genome mutation frequencies and Equation [9]. With a rate of 10-9 mutations per base per division, mutations accumulate with aging in mitotic tissues. Cancer genomes generally have less than one somatic mutation per 100,000 bases (dotted line). A division rate of once every four days rather than once a day is more consistent with observed cancer genome mutation frequencies. In our model, most cancer somatic mutations accumulate earlier in life in normal appearing stem cells (Fig 1).

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