Skip to main content

Advertisement

Figure 3 | BMC Cancer

Figure 3

From: A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates

Figure 3

Division rates can be inferred from cancer genome mutation frequencies and Equation [9]. With a rate of 10-9 mutations per base per division, mutations accumulate with aging in mitotic tissues. Cancer genomes generally have less than one somatic mutation per 100,000 bases (dotted line). A division rate of once every four days rather than once a day is more consistent with observed cancer genome mutation frequencies. In our model, most cancer somatic mutations accumulate earlier in life in normal appearing stem cells (Fig 1).

Back to article page