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Table 1 MBD-mediated repression of CD44, Cyclin D2, GLIPR1 and PTEN

From: Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications

Repression (%) Gal4-linked promoter Gal4BD-TRDs methylated promoter
full length proteins
unmethylated promoter
full length proteins
   MBD1 MBD2 MeCP2 MBD1v1 MBD1v3 MBD2a MBD2b MeCP2 MBD1v1 MBD1v3
CD44 MCF-7 55 - 20 85 5 - - 45 75 -
  DU145 75 - 55 80 25 - - 10 75 25
  LNCaP 30 - - 35 - - - - 70 20
Cyclin D2 MCF-7 65 50 65 90 45 50 45 90 75 50
  DU145 30 - 15 65 30 5 - 50 20 -
  LNCaP 15 25 20 45 50 40 40 65 30 -
GLIPR MCF-7 20 - 20 50 10 - - 80 40 -
  DU145 85 45 85 35 - 60 45 65 50 -
  LNCaP 20 - - 20 25 - - - 20 -
PTEN MCF-7 30 - 15 95 10 45 20 75 75 25
  DU145 80 - 85 75 - - - - 50 25
  LNCaP 20 10 20 30 20 45 35 55 65 -
  1. -, no repression