angioreactor-based in vivo assay. A. Directed in vivo angiogenesis assay (DIVAA) showing silicone tubes with and without application of pentastatin-1 at 200 μg/mL. Angioreactors were implanted subcutaneously into the abdominal region of C57BL/6 mice for 12 days, and vessels allowed to infiltrate. B. Peptides were mixed at concentrations of 30, 50, 100, and 200 μg/mL with Matrigel (BD Biosciences, San Jose, CA), and vascularization assayed and scaled where 100% represents the mean of the untreated controls (Ctrl). Results are significantly less than controls at p < 0.05 *.