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Figure 4 | BMC Cancer

Figure 4

From: ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors

Figure 4

Blood vessel morphology in tumor xenografts. Blood vessels were stained for CD34 and morphology was evaluated in light microscopy at 200 × magnification. Tumors characterized by large and thick, singly distributed vessels, often with a visible lumen were assigned as LV = large vessels, while tumors characterized by small and thin vessels forming networks without a visible lumen were assigned as SV = small vessels. (A) Images showing the blood vessel morphology in typical LV and SV tumors in LNCaP and LNCaP-19 tumors with modified ADAMTS1. (B) Tumors were classified unaware of origin into LV or SV. Histograms show the distribution of tumors between LV and SV in LNCaP tumors (upper panel); control transfected LNCaP (LC, n = 8) and shRNA transfected LNCaP (LA-, n = 6) and in LNCaP-19 tumors (lower panel); control transfected LNCaP-19 (L19C, n = 8) and ADAMTS1 transfected LNCaP-19 (L19A+, n = 7).

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