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Figure 2 | BMC Cancer

Figure 2

From: ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors

Figure 2

Growth of LNCaP clones in vivo and in vitro. LNCaP cells were implanted subcutaneously in nude mice and the experiment was ended when tumor size reached about 1.3 cm3, or after a maximum of 15 weeks. LNCaP wild-type (L wt, n = 8), control transfected LNCaP (LC, n = 8) and ADAMTS1 shRNA-transfected LNCaP (LA-, n = 7). (A) Tumor take rate is presented as percentage of animals with a palpable tumor at different time points after implantation. Fisher's exact test was used to compare the tumor take rate between groups. (B) Tumor growth rate was calculated as tumor weight (mg) divided with the number of days from implantation to sacrifice and presented as the relative growth rate compared to wild-type tumors. Results are presented as mean ± SEM. Mann Whitney U test was used to compare differences between groups, ** = P < 0.01. (C) Tumor volumes were calculated as (length × width2)/2. (D) Proliferation rate in vitro of LC and LA- in relation to L wt. Cells were seeded in 96-well plates in their regular cell culture medium. Four days later, DNA was quantified by a fluorescent dye and values were related to the wild-type cells. Mean ± SEM of two independent experiments with triplicates are shown.

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