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Figure 2 | BMC Cancer

Figure 2

From: Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

Figure 2

PIAs did not reduce AKT activity under full supplemented culture conditions. (A) Western blot analysis of colorectal cancer cells treated with either specific PI3 kinase inhibitors (LY294002, Wortmannin) or PIAs (SH-5, SH-6) for 2 and 48 hours, respectively. DMSO served as the solvent control. Levels of phosphorylated AKT were determined using specific antibodies. Total AKT was determined as a loading control. (B) Morphological alterations induced by the PIAs after 48 hours of treatment.

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