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Table 7 Genotype frequencies of CXCR2 (+1208) C/T polymorphism in relation to pathological indices of Breast Cancer severity

From: Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

Genotypes

Number of patients (%)

Crude OR (95% CI)

P-valuea

Adjusted OR (95% CI)b

P-value

Clinical tumor size

T1-T2

T3-T4

    

CC

117 (48.75)

51 (33.55)

1

 

1

 

CT

89 (37.08)

62 (40.79)

1.60 [0.98-2.61]

0.04

1.73 [1.01-2.76]

0.03

TT

34 (14.17)

39 (25.66)

2.63 [1.44-4.82]

0.0006

2.89 [1.64-5.06]

0.0004

Alleles

      

C-allele

323 (67.29)

164 (53.95)

    

T-allele

157 (32.71)

140 (46.05)

1.76 [1.29-2.39]

0.0001

1.98 [1.47-2.56]

0.0001

Lymph nodes status

Negative

Positive

    

CC

94 (51.93)

81 (38.39)

1

 

1

 

CT

69 (38.12)

89 (42.18)

1.50 [0.95-2.36]

0.06

1.45 [0.98-2.27]

0.07

TT

18 (9.95)

41 (19.43)

2.64 [1.35-5.21]

0.002

2.72 [1.44-5.43]

0.001

Alleles

      

C-allele

257 (70.99)

251 (59.48)

    

T-allele

105 (29.01)

171 (40.52)

1.67 [1.22-2.27]

0.0007

1.83 [1.32-2.46]

0.0008

SBR grading

1-2

3

    

CC

91 (44.39)

63 (38.18)

1

 

1

 

CT

85 (41.46)

64 (38.78)

1.09 [0.67-1.76]

0.71

1.12 [0.78-1.89]

0.65

TT

29 (14.15)

38 (23.03)

1.89 [1.02-3.53]

0.03

1.98 [1.15-3.79]

0.02

Alleles

      

C-allele

267 (65.12)

190 (57.58)

    

T-allele

143 (34.88)

140 (42.42)

1.38 [1.01-1.87]

0.03

1.67 [1.08-2.03]

0.01

Estrogen receptor status

Positive

Negative

    

CC

50 (30.87)

48 (33.33)

1

 

1

 

CT

76 (46.91)

60 (41.67)

1.22 [0.70-2.12]

0.46

1.34 [0.78-2.34]

0.35

TT

36 (22.22)

36 (25.00)

0.96 [0.50-1.85]

0.89

0.87 [0.54-1.89]

0.85

Alleles

      

C-allele

176 (54.32)

156 (54.17)

    

T-allele

148 (45.68)

132 (45.83)

0.99 [0.71-1.38]

0.96

0.95 [0.66-1.27]

0.87

  1. a P-value determined by χ2 test.
  2. b ORs were adjusted for age, BMI, history of benign disease, and oral contraceptive drugs usage.