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Table 3 Association statistics for CCR2-V64I genotypes according to cytology in the control group

From: CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

 

Normal cytology (n = 1070)

Abnormal cytology (n = 185)

  
 

Black 210 (20)

Mixed-ancestry 860 (80)

Black 64 (35)

Mixed-ancestry 121 (65)

Genotype-abnormal cytology association, adjusted for ethnicity and smoking

Genotypes

n (%)

n (%)

n (%)

n (%)

P-value

OR (95% CI)

CCR2 G→A

     

GG

124 (59)

563 (66)

45 (70)

78 (64)

-

1

AG

84 (40)

287 (33)

17 (27)

40 (33)

0.290

0.83 (0.59-1.17)

AA

2 (1)

10 (1)

2 (3)

3 (3)

0.134

2.28 (0.78-6.69)

AG + AA

86 (41)

297 (35)

19 (30)

43 (36)

0.437

0.88 (0.63-1.22)

  1. Abnormal cytology = Positive for pap smear test (i.e. positive for ASCUS + positive for LSIL + positive for HSIL), Normal cytology = Negative for pap smear test.