Skip to main content

Table 1 Counts (n), frequencies (%) and association statistics for CCR2-V64I genotypes for cases and controls

From: CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

 

Controls (n = 1378)

Cases (n = 446)

  
 

Black 305 (n = 22)

Mixed-ancestry 1073 (n = 78)

Black 106 (n = 24)

Mixed-ancestry 340 (n = 76)

Genotype-cervical cancer association, adjusted for ethnicity and smoking

Genotypes

n (%)

n (%)

n (%)

n (%)

P-value

OR (95% CI)

CCR2 G→A

     

GG

189 (62)

704 (66)

24 (23)

78 (23)

-

1

AG

112 (37)

356 (33)

81 (76)

255 (75)

0.001

6.22 (4.85-7.97)

AA

4 (1)

13 (1)

1 (1)

7 (2)

0.002

3.99 (1.68-9.50)

AG + AA

116 (38)

369 (34)

82 (77)

262 (77)

0.001

6.14 (4.79-7.86)

  1. P-values and OR (95% confidence intervals) are for test of genotype or additive allelic association with cervix cancer risk, adjusted for ethnicity and smoking. P-values next to genotype names are for joint model, others are for ORs of specific genotype compared to reference genotype, indicated with OR = 1. Cases = Women with cancer of the cervix (ICC), Controls = Women without cancer of the cervix.