Table 5 Combinations of CYP1A1 and NQO1 polymorphisms and colorectal cancer risk
| Â | Â | Number (%) | Â | Â | |
|---|---|---|---|---|---|
Combination of genotypes | Â | Cases | Controls | OR (95% CI)* | Pfor interaction |
CYP1A1*2A | NQO1 Pro187Ser†|  |  |  |  |
   0‡ | Pro/Pro | 126 (18.4) | 118 (15.2) | 1.00 (referent) |  |
   ≥1 | Pro/Pro | 133 (19.4) | 164 (21.1) | 0.78 (0.55-1.10) | 0.22 |
   0 | Pro/Ser + Ser/Ser | 157 (23.0) | 187 (24.1) | 0.81 (0.58-1.14) |  |
   ≥1 | Pro/Ser + Ser/Ser | 268 (39.2) | 308 (39.6) | 0.83 (0.61-1.13) |  |
CYP1A1*2C | NQO1 Pro187Ser†|  |  |  |  |
   0‡ | Pro/Pro | 162 (23.7) | 176 (22.7) | 1.00 (referent) |  |
   ≥1 | Pro/Pro | 97 (14.2) | 106 (23.6) | 1.04 (0.73-1.48) | 0.53 |
   0 | Pro/Ser + Ser/Ser | 256 (37.4) | 285 (36.7) | 1.00 (0.76-1.32) |  |
   ≥1 | Pro/Ser + Ser/Ser | 169 (24.7) | 210 (27.0) | 0.90 (0.67-1.22) |  |