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Table 3 Effect modification of cigarette smoking on colorectal cancer risk associated with selected genetic polymorphisms

From: Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study

 

< 400

≥ 400

 

Genotype

n*

OR (95% CI)†

n*

OR (95% CI)†

Pfor interaction

CYP1A1*2A

     

   0‡

161/207

1.00 (referent)

122/98

1.76 (1.19-2.59)

0.14

   ≥1

255/320

1.04 (0.79-1.36)

147/153

1.30 (0.91-1.87)

 

CYP1A1*2C

     

   0‡

243/309

1.00 (referent)

175/152

1.58 (1.14-2.20)

0.30

   ≥1

173/218

1.03 (0.79-1.34)

94/99

1.28 (0.87-1.86)

 

GSTM1

     

   Non-null

207/245

1.00 (referent)

121/111

1.38 (0.96-1.97)

0.68

   Null

209/282

0.88 (0.67-1.14)

148/140

1.33 (0.94-1.87)

 

GSTT1

     

   Non-null

211/301

1.00 (referent)

136/134

1.51 (1.08-2.13)

0.60

   Null

205/226

1.24 (0.95-1.61)

133/117

1.67 (1.18-2.37)

 

GSTM1+GSTT1

     

   Non-null

304/407

1.00 (referent)

198/182

1.53 (1.14-2.07)

0.29

   Null

112/120

1.20 (0.89-1.63)

71/69

1.41 (0.94-2.11)

 

NQO1 Pro187Ser§

     

   Pro/Pro

157/189

1.00 (referent)

102/93

1.41 (0.95-2.09)

0.89

   Pro/Ser + Ser/Ser

259/338

0.94 (0.72-1.24)

166/157

1.37 (0.96-1.94)

 
  1. * Numbers of cases/controls.
  2. † Adjusted for sex, age, residence area, alcohol consumption, body mass index, type of job, leisure-time physical activity and parental colorectal cancer.
  3. ‡ Number of the variant allele.
  4. § One case and one control were excluded because of undetermined genotype.