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Table 1 Predictive value of relative mRNA expression levels for identifying high-grade gliomas

From: Differential expression of centrosomal proteins at different stages of human glioma

  

Group

 

mRNA

Low-grade glioma (n= 11)

High-grade glioma (n= 23)

p-value

hNinein isoform 1

Absent

0

(0%)

1

(4.3%)

0.741

 

Rare

9

(81.8%)

13

(56.5%)

 
 

Moderate

2

(18.2%)

8

(34.8%)

 
 

Abundant

0

(0%)

1

(4.3%)

 

hNinein isoform 2

Absent

2

(18.2%)

0

(0%)

0.254

 

Rare

7

(63.6%)

18

(78.3%)

 
 

Moderate

2

(18.2%)

4

(17.4%)

 
 

Abundant

0

(0%)

1

(4.3%)

 

hNinein isoform 5

Absent

1

(9.1%)

0

(0%)

0.501

 

Rare

8

(72.7%)

15

(65.2%)

 
 

Moderate

2

(18.2%)

7

(30.4%)

 
 

Abundant

0

(0%)

1

(4.3%)

 

hNinein isoform 6

Absent

3

(27.3%)

14

(60.9%)

0.141

 

Rare

8

(72.7%)

9

(39.1%)

 
 

Moderate

0

(0%)

0

(0%)

 
 

Abundant

0

(0%)

0

(0%)

 

γ-tubulin

Absent

0

(0%)

0

(0%)

0.005*

 

Rare

9

(81.8%)

5

(21.7%)

 
 

Moderate

2

(18.2%)

14

(60.9%)

 
 

Abundant

0

(0%)

4

(17.4%)

 

Aurora A

Absent

3

(27.3%)

0

(0%)

0.030*

 

Rare

8

(72.7%)

20

(87.0%)

 
 

Moderate

0

(0%)

3

(13.0%)

 
 

Abundant

0

(0%)

0

(0%)

 

Aurora B

Absent

3

(27.3%)

4

(17.4%)

0.653

 

Rare

6

(54.5%)

16

(69.6%)

 
 

Moderate

2

(18.2%)

3

(13.0%)

 
 

Abundant

0

(0%)

0

(0%)

 

Centrin 2

Absent

2

(18.2%)

1

(4.3%)

0.235

 

Rare

2

(18.2%)

6

(26.1%)

 
 

Moderate

5

(45.5%)

15

(65.2%)

 
 

Abundant

2

(18.2%)

1

(4.3%)

 

Centrin 3

Absent

1

(9.1%)

1

(4.3%)

0.536

 

Rare

3

(27.3%)

3

(13.0%)

 
 

Moderate

3

(27.3%)

5

(21.7%)

 
 

Abundant

4

(36.4%)

14

(60.9%)

 
  1. NOTE: In normal brain tissue Aurora A, Aurora B, and Centrin 2 mRNAs were absent and hNinein isoforms 1, 2, 5, and 6, γ-tubulin, and Centrin 3 mRNAs were rare.
  2. * P < 0.05 by Fisher's exact test