Human Papilloma Virus prevalence and type-specific relative contribution in invasive cervical cancer specimens from Italy

Table 4 The five most common HPV types (HPV type-specific prevalence) in ICC specimens for any histology: Worldwide, Europe, Southern Europe region and neighbourhood European countries

HPV Position	Italy^a	World^b	Europe^b	Southern Europe^b	Austria^b	Croatia^b	France^b	Germany^b	Greece^b	Spain^b
1 ^st	HPV16 (53.7%)	HPV16 (54.4%)	HPV16 (57.7%)	HPV16 (48.5%)	HPV16 (70.0%)	HPV16 (45.0%)	HPV16 (60.7%)	HPV16 (58.0%)	HPV16 (22.2%)	HPV16 (51.0%)
2 ^nd	HPV18 (9.7%)	HPV18 (16.5%)	HPV18 (16.8%)	HPV18 (13.6%)	HPV33 (21.5%)	HPV18 (36.9%)	HPV18 (14.9%)	HPV18 (18.8%)	HPV18 (19.1%)	HPV31 (5.3%)
3 ^rd	HPV31 (5.2%)	HPV58 (5.1%)	HPV33 (4.3%)	HPV31 (6.5%)	HPV18 (8.5%)	HPV51 (17.6%)	HPV31 (3.8%)	HPV52/68 (5.6%)	HPV6 (3.8%)	HPV18 (4.9%)
4 ^th	HPV45/58 (4.5%)	HPV33 (4.7%)	HPV31 (4.1%)	HPV33 (4.9%)	HPV45 (4.5%)	HPV31/33 (11.7%)	HPV33/68 (3.3%)	HPV31 (2.9%)	HPV51 (2.9%)	HPV45 (4.1%)
5 ^th	HPV33 (3.0%)	HPV45 (4.4%)	HPV45 (3.5%)	HPV45 (3.3%)	HPV31 (4.0%)	HPV45 (2.7%)	HPV45 (2.9%)	HPV35 (1.4%)	HPV33 (2.8%)	HPV33 (3.0%)

a) Data for Italy: extracted from the present study.
b) Source of information: WHO/ICO Information Centre on Human Papillomavirus (HPV) and Cervical Cancer http://www.who.int/hpvcentre/statistics/en/ (ref.[23]); Selection of regions: World, Europe, Southern Europe (Albania, Andorra, Bosnia & Herzegovina, Croatia, Greece, Italy, Macedonia, TFYR, Malta, Montenegro, Portugal, San Marino, Serbia, Slovenia, Spain), and neighbourhood European countries; No data available for: Bosnia & Herzegovina, Montenegro, Slovenia and Switzerland.
Methods for counting HPV type-specific prevalence: HPV single and multiple infections counted once in each HPV type; prevalence: HPV positive cases for a specific HPV type among HPV analyzed cases.

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