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Table 2 Time-dependent ROC analysis of the candidate genes in the training and validation set of LNP patients with ER+ tumors treated with adjuvant anthracycline containing therapy.

From: CDO1 Promoter Methylation is a Biomarker for Outcome Prediction of Anthracycline Treated, Estrogen Receptor-Positive, Lymph Node-Positive Breast Cancer Patients

 

Training Set (n = 84)

Validation Set (n = 78)

Gene

AUC

p-value

AUC

p-value

CDO1

0.70

0.0034

0.69

0.0010

APC

0.68

0.0204

0.55

0.5306

ZBTB16

0.67

0.0224

0.63

0.0582

NCR1

0.63

0.0239

0.56

0.9048

POU4F3

0.69

0.0248

0.69

0.0754

CXCL12

0.67

0.0282

0.49

0.4854

  1. Shown are the AUC of the ROC at 48 months after surgery
  2. The p-values are those obtained by the log rank test in Kaplan-Meier survival analysis and the genes are ranked according these p-values. The median DNA methylation score from the training set and the validation set, respectively, was used as the cut point.