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Table 1 Characteristics of the 162 estrogen receptor-positive and lymph node positive breast cancer patients treated with anthracyclines.

From: CDO1 Promoter Methylation is a Biomarker for Outcome Prediction of Anthracycline Treated, Estrogen Receptor-Positive, Lymph Node-Positive Breast Cancer Patients

 

Training Set

Validation Set

 

All

Distant Metastasis

All

Distant Metastasis

Total Number of Patients

84 (100%)

39

78 (100%)

25

Follow-up

    

Median follow-up [Months]

80

  

53.5

Range [Months]

6-144

 

5-166

 

Age at Diagnosis

    

≤ 50 Years

38 (45%)

20

41 (53%)

16

> 50 Years

46 (55%)

19

37 (47%)

19

Median Age (Years)

49

 

49

 

Range (Years)

29-71

  

33 - 81

T stage

    

≤ 2 cm (T1)

19 (23%)

4

24 (31%)

5

> 2 cm (T2+T3)

63 (75%)

35

53 (68%)

19

Unknown

2 (2%)

0

1 (1%)

1

Tumor Grade

    

G1

2 (2%)

0

3 (4%)

1

G2

24 (29%)

11

30 (38%)

7

G3

47 (56%)

21

28 (36%)

11

Unknown

11 (13%)

7

17 (22%)

6

Estrogen Receptor Status

    

Negative

0

0

0

0

Positive

84 (100%)

39

78 (100%)

25

Progesterone Receptor Status

    

Negative

12 (14%)

4

18 (23%)

9

Positive

72 (86%)

35

60 (77%)

16

Endocrine Treatment

    

Yes

22 (26%)

8

37 (47%)

9

No

61 (73%)

30

40 (51%)

15

Unknown

1 (1%)

1

1 (1%)

1

  1. The training set was enriched for specimens that lack PITX2 methylation.