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Figure 5 | BMC Cancer

Figure 5

From: Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Figure 5

LV-Kallistatin inhibited the inflammation in tumors. Mice bearing LL2 or LL2/NF-κBLuc tumors at day 0 were injected with LV-GFP, LV-Kallistatin (108 TU) or with saline at day 1. (A) Tumors were excised at day 20, immunostained with antibodies against F4/80 (×200). (B) Macrophages were determined by averaging the cell numbers from three fields of highest positive-stained cell density at ×200 magnification in each section (mean ± SEM, n = 3~4). (*p < 0.05) Tumor-bearing mice were treated with LV-Kallistatin, LV-GFP (108 TU) or saline, and their lungs were collected at day 12. The levels of TNF-α (C), and VEGF (D) were measured by using ELISA. (E) The luciferase activities in tumors were measured at day 17. (mean ± SD n = 3~4, *p < 0.05, **p < 0.01).

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