Figure 1
Effect of 17β-estradiol or 17β-estradiol combined with ICI 182,780 on human CRPC xenograft growth in SCID mice. Castrated SCID male mice were implanted with LuCaP 35V castration resistant cells and when tumors reached 150-400 mm3, treated with placebo pellets (n = 10): 17β-estradiol by subcutaneous pellets (n = 10); or 17β-estradiol pellets and ICI 182,780 (5 mg/kg SC once per week) as detailed in Materials and Methods. Data shown are Kaplan-Meier estimates of survival for tumor bearing animals treated with indicated agents.