BMC Cancer

Table 3 Interaction between MTHFR C677T polymorphisms and smoking and drinking habit and age for gastric and colorectal cancer risk.

From: Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population

	CT vs CC*	TT vs CC*	pfor interaction^a
	OR^a(95%CI)	OR^a(95%CI)
gastric cancer
Smoking habit
Never	0.874(0.693-1.102	0.984(0.722-1.339)
Ever	0.776(0.632-0.952)	0.825(0.630-1.079)	0.680
Drinking habit
Non-drinker	0.801(0.651-0.986)	0.853(0.647-1.124)
Drinker	0.827(0.656-1.042)	0.959(0.707-1.299)	0.847
Age
≤ 65 years	0.852(0.711-1.020)	0.921(0.726-1.167)
>65 years	0.700(0.529-0.925)	0.765(0.530-1.103)	0.581
colorectal cancer
Smoking habit
Never	0.993(0.762-1.293)	0.955(0.670-1.363)
Ever	0.851(0.688-1.053)	0.666(0.499-0.888)	0.301
Drinking habit
Non-drinker	0.854(0.689-1.059)	0.712(0.532-0.954)
Drinker	0.950(0.735-1.229)	0.878(0.620-1.243)	0.635
Age
≤ 65 years	0.966(0.819-1.211)	0.810(0.620-1.059)
>65 years	0.789(0.597-1.043)	0.759(0.525-1.099)	0.361

OR^a ,adjusted for age and sex; CC*, CC as reference group
Interaction^a was modeled as a product of smoking habit (0, never and 1, ever),
drinking habit (0,non-drinker and 1, drinker), age (0, ≤ 65 years and 1, >65 years) and genotype in score (0, CC genotype for reference allele; 1, CT genotype and 2, TT genotype)

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com