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Table 2 CDC25C and phospho-CDC25C (Ser216) immunostaining in relation to clinicopathological variables

From: Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes

Variables Total CDC25C Phospho-CDC25C (Ser216)
   Cytoplasm Cytoplasm Nucleus
  n Low High (%) p 1 Low High (%) p 1 Low High (%) p 1
Age     0.91    0.91    0.45
   25-69 119 46 73 (61)   61 58 (49)   40 79 (66)  
   70-84 147 53 94 (64)   71 76 (52)   39 108 (74)  
   85+ 34 13 21 (62)   17 17 (50)   10 24 (71)  
FIGO     0.004    0.05    0.01
   Ia 11 5 6 (55)   7 4 (36)   6 5 (46)  
   Ib 35 23 12 (34)   24 11 (31)   17 18 (51)  
   II 110 38 72 (66)   55 55 (50)   25 85 (77)  
   III 121 38 83 (69)   55 66 (55)   32 89 (74)  
   IV 19 6 13 (68)   6 13 (68)   6 13 (68)  
   Not available 4          
Lymph node metastases     0.04    0.14    0.54
   None 136 58 78 (57)   78 58 (43)   40 96 (71)  
   Unilateral 76 21 55 (72)   33 43 (57)   19 57 (75)  
   Bilateral 34 9 25 (74)   16 18 (53)   7 27 (79)  
   Not available 54          
Tumour diameter (cm)     0.03    < 0.001    0.009
   0.3-2.5 90 41 49 (54)   60 30 (33)   35 55 (61)  
   2.6-4.0 94 34 60 (64)   46 48 (51)   21 73 (78)  
   4.1-20.0 100 27 73 (73)   35 65 (65)   21 79 (79)  
   Not available 16          
Tumor differentiation     0.03    < 0.001    0.30
   Well 74 37 37 (50)   51 23 (31)   18 56 (76)  
   Moderate 154 53 101 (66)   74 80 (52)   45 109 (71)  
   Poor 72 22 50 (69)   24 48 (67)   26 46 (64)  
Depth of invasion (mm)     0.08    0.01    0.01
   0.0-4.0 79 34 45 (57)   50 29 (37)   32 47 (60)  
   4.1-8.0 98 27 71 (72)   48 50 (51)   21 77 (79)  
   8.1-40.0 112 44 68 (61)   46 66 (59)   27 85 (76)  
   Not available 11          
Infiltration of vessel     0.32    0.26    0.54
   No 232 91 141 (61)   119 113 (49)   71 161 (69)  
   Yes 65 21 44 (68)   28 37 (57)   17 48 (74)  
   Not available 3          
HPV2     0.29    0.09    < 0.001
   Low (-) 167 57 110 (66)   99 68 (41)   32 135 (81)  
   High (+) 43 19 24 (56)   19 24 (56)   21 22 (51)  
   Not available 90          
14-3-3σ cytoplasm2     0.001    0.007    < 0.001
   Low (< 6) 83 43 40 (48)   52 31 (37)   39 44 (53)  
   High (≥ 6) 217 69 148 (68)   97 120 (55)   50 167 (77)  
14-3-3σ nucleus2     0.40    0.48    < 0.001
   Low (< 6) 123 42 81 (66)   58 65 (53)   51 72 (59)  
   High (≥ 6) 177 70 107 (61)   91 86 (49)   38 139 (79)  
14-3-3σ cytoplasm/nucleus2     0.001    0.005    < 0.001
   Low (< 6) 75 40 35 (47)   48 27 (36)   36 39 (52)  
   High (≥ 6) 225 72 153 (68)   101 124 (55)   53 172 (76)  
CDC25A     0.48    0.49    0.002
   Low 148 52 96 (65)   77 71 (48)   31 117 (79)  
   High 152 60 92 (61)   72 80 (53)   58 94 (62)  
CDC25B     0.87    0.01    0.13
   Low 253 95 158 (63)   134 119 (47)   74 179 (71)  
   High 47 17 30 (64)   15 32 (68)   15 32 (68)  
CDC25C     -    < 0.001    < 0.001
   Low 112 - - -   76 36 (32)   47 65 (58)  
   High 188 - - -   73 115 (61)   42 146 (78)  
  1. 1 Pearson chi-square
  2. 2 In previous reports, 14-3-3σ and HPV have been studied [18, 19].