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Table 2 CDC25C and phospho-CDC25C (Ser216) immunostaining in relation to clinicopathological variables

From: Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes

Variables

Total

CDC25C

Phospho-CDC25C (Ser216)

  

Cytoplasm

Cytoplasm

Nucleus

 

n

Low

High (%)

p 1

Low

High (%)

p 1

Low

High (%)

p 1

Age

   

0.91

  

0.91

  

0.45

   25-69

119

46

73 (61)

 

61

58 (49)

 

40

79 (66)

 

   70-84

147

53

94 (64)

 

71

76 (52)

 

39

108 (74)

 

   85+

34

13

21 (62)

 

17

17 (50)

 

10

24 (71)

 

FIGO

   

0.004

  

0.05

  

0.01

   Ia

11

5

6 (55)

 

7

4 (36)

 

6

5 (46)

 

   Ib

35

23

12 (34)

 

24

11 (31)

 

17

18 (51)

 

   II

110

38

72 (66)

 

55

55 (50)

 

25

85 (77)

 

   III

121

38

83 (69)

 

55

66 (55)

 

32

89 (74)

 

   IV

19

6

13 (68)

 

6

13 (68)

 

6

13 (68)

 

   Not available

4

         

Lymph node metastases

   

0.04

  

0.14

  

0.54

   None

136

58

78 (57)

 

78

58 (43)

 

40

96 (71)

 

   Unilateral

76

21

55 (72)

 

33

43 (57)

 

19

57 (75)

 

   Bilateral

34

9

25 (74)

 

16

18 (53)

 

7

27 (79)

 

   Not available

54

         

Tumour diameter (cm)

   

0.03

  

< 0.001

  

0.009

   0.3-2.5

90

41

49 (54)

 

60

30 (33)

 

35

55 (61)

 

   2.6-4.0

94

34

60 (64)

 

46

48 (51)

 

21

73 (78)

 

   4.1-20.0

100

27

73 (73)

 

35

65 (65)

 

21

79 (79)

 

   Not available

16

         

Tumor differentiation

   

0.03

  

< 0.001

  

0.30

   Well

74

37

37 (50)

 

51

23 (31)

 

18

56 (76)

 

   Moderate

154

53

101 (66)

 

74

80 (52)

 

45

109 (71)

 

   Poor

72

22

50 (69)

 

24

48 (67)

 

26

46 (64)

 

Depth of invasion (mm)

   

0.08

  

0.01

  

0.01

   0.0-4.0

79

34

45 (57)

 

50

29 (37)

 

32

47 (60)

 

   4.1-8.0

98

27

71 (72)

 

48

50 (51)

 

21

77 (79)

 

   8.1-40.0

112

44

68 (61)

 

46

66 (59)

 

27

85 (76)

 

   Not available

11

         

Infiltration of vessel

   

0.32

  

0.26

  

0.54

   No

232

91

141 (61)

 

119

113 (49)

 

71

161 (69)

 

   Yes

65

21

44 (68)

 

28

37 (57)

 

17

48 (74)

 

   Not available

3

         

HPV2

   

0.29

  

0.09

  

< 0.001

   Low (-)

167

57

110 (66)

 

99

68 (41)

 

32

135 (81)

 

   High (+)

43

19

24 (56)

 

19

24 (56)

 

21

22 (51)

 

   Not available

90

         

14-3-3σ cytoplasm2

   

0.001

  

0.007

  

< 0.001

   Low (< 6)

83

43

40 (48)

 

52

31 (37)

 

39

44 (53)

 

   High (≥ 6)

217

69

148 (68)

 

97

120 (55)

 

50

167 (77)

 

14-3-3σ nucleus2

   

0.40

  

0.48

  

< 0.001

   Low (< 6)

123

42

81 (66)

 

58

65 (53)

 

51

72 (59)

 

   High (≥ 6)

177

70

107 (61)

 

91

86 (49)

 

38

139 (79)

 

14-3-3σ cytoplasm/nucleus2

   

0.001

  

0.005

  

< 0.001

   Low (< 6)

75

40

35 (47)

 

48

27 (36)

 

36

39 (52)

 

   High (≥ 6)

225

72

153 (68)

 

101

124 (55)

 

53

172 (76)

 

CDC25A

   

0.48

  

0.49

  

0.002

   Low

148

52

96 (65)

 

77

71 (48)

 

31

117 (79)

 

   High

152

60

92 (61)

 

72

80 (53)

 

58

94 (62)

 

CDC25B

   

0.87

  

0.01

  

0.13

   Low

253

95

158 (63)

 

134

119 (47)

 

74

179 (71)

 

   High

47

17

30 (64)

 

15

32 (68)

 

15

32 (68)

 

CDC25C

   

-

  

< 0.001

  

< 0.001

   Low

112

-

- -

 

76

36 (32)

 

47

65 (58)

 

   High

188

-

- -

 

73

115 (61)

 

42

146 (78)

 
  1. 1 Pearson chi-square
  2. 2 In previous reports, 14-3-3σ and HPV have been studied [18, 19].