Variables | Total | CDC25C | Phospho-CDC25C (Ser216) | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Cytoplasm | Cytoplasm | Nucleus | ||||||||
n | Low | High (%) | p 1 | Low | High (%) | p 1 | Low | High (%) | p 1 | |
Age | 0.91 | 0.91 | 0.45 | |||||||
25-69 | 119 | 46 | 73 (61) | 61 | 58 (49) | 40 | 79 (66) | |||
70-84 | 147 | 53 | 94 (64) | 71 | 76 (52) | 39 | 108 (74) | |||
85+ | 34 | 13 | 21 (62) | 17 | 17 (50) | 10 | 24 (71) | |||
FIGO | 0.004 | 0.05 | 0.01 | |||||||
Ia | 11 | 5 | 6 (55) | 7 | 4 (36) | 6 | 5 (46) | |||
Ib | 35 | 23 | 12 (34) | 24 | 11 (31) | 17 | 18 (51) | |||
II | 110 | 38 | 72 (66) | 55 | 55 (50) | 25 | 85 (77) | |||
III | 121 | 38 | 83 (69) | 55 | 66 (55) | 32 | 89 (74) | |||
IV | 19 | 6 | 13 (68) | 6 | 13 (68) | 6 | 13 (68) | |||
Not available | 4 | |||||||||
Lymph node metastases | 0.04 | 0.14 | 0.54 | |||||||
None | 136 | 58 | 78 (57) | 78 | 58 (43) | 40 | 96 (71) | |||
Unilateral | 76 | 21 | 55 (72) | 33 | 43 (57) | 19 | 57 (75) | |||
Bilateral | 34 | 9 | 25 (74) | 16 | 18 (53) | 7 | 27 (79) | |||
Not available | 54 | |||||||||
Tumour diameter (cm) | 0.03 | < 0.001 | 0.009 | |||||||
0.3-2.5 | 90 | 41 | 49 (54) | 60 | 30 (33) | 35 | 55 (61) | |||
2.6-4.0 | 94 | 34 | 60 (64) | 46 | 48 (51) | 21 | 73 (78) | |||
4.1-20.0 | 100 | 27 | 73 (73) | 35 | 65 (65) | 21 | 79 (79) | |||
Not available | 16 | |||||||||
Tumor differentiation | 0.03 | < 0.001 | 0.30 | |||||||
Well | 74 | 37 | 37 (50) | 51 | 23 (31) | 18 | 56 (76) | |||
Moderate | 154 | 53 | 101 (66) | 74 | 80 (52) | 45 | 109 (71) | |||
Poor | 72 | 22 | 50 (69) | 24 | 48 (67) | 26 | 46 (64) | |||
Depth of invasion (mm) | 0.08 | 0.01 | 0.01 | |||||||
0.0-4.0 | 79 | 34 | 45 (57) | 50 | 29 (37) | 32 | 47 (60) | |||
4.1-8.0 | 98 | 27 | 71 (72) | 48 | 50 (51) | 21 | 77 (79) | |||
8.1-40.0 | 112 | 44 | 68 (61) | 46 | 66 (59) | 27 | 85 (76) | |||
Not available | 11 | |||||||||
Infiltration of vessel | 0.32 | 0.26 | 0.54 | |||||||
No | 232 | 91 | 141 (61) | 119 | 113 (49) | 71 | 161 (69) | |||
Yes | 65 | 21 | 44 (68) | 28 | 37 (57) | 17 | 48 (74) | |||
Not available | 3 | |||||||||
HPV2 | 0.29 | 0.09 | < 0.001 | |||||||
Low (-) | 167 | 57 | 110 (66) | 99 | 68 (41) | 32 | 135 (81) | |||
High (+) | 43 | 19 | 24 (56) | 19 | 24 (56) | 21 | 22 (51) | |||
Not available | 90 | |||||||||
14-3-3σ cytoplasm2 | 0.001 | 0.007 | < 0.001 | |||||||
Low (< 6) | 83 | 43 | 40 (48) | 52 | 31 (37) | 39 | 44 (53) | |||
High (≥ 6) | 217 | 69 | 148 (68) | 97 | 120 (55) | 50 | 167 (77) | |||
14-3-3σ nucleus2 | 0.40 | 0.48 | < 0.001 | |||||||
Low (< 6) | 123 | 42 | 81 (66) | 58 | 65 (53) | 51 | 72 (59) | |||
High (≥ 6) | 177 | 70 | 107 (61) | 91 | 86 (49) | 38 | 139 (79) | |||
14-3-3σ cytoplasm/nucleus2 | 0.001 | 0.005 | < 0.001 | |||||||
Low (< 6) | 75 | 40 | 35 (47) | 48 | 27 (36) | 36 | 39 (52) | |||
High (≥ 6) | 225 | 72 | 153 (68) | 101 | 124 (55) | 53 | 172 (76) | |||
CDC25A | 0.48 | 0.49 | 0.002 | |||||||
Low | 148 | 52 | 96 (65) | 77 | 71 (48) | 31 | 117 (79) | |||
High | 152 | 60 | 92 (61) | 72 | 80 (53) | 58 | 94 (62) | |||
CDC25B | 0.87 | 0.01 | 0.13 | |||||||
Low | 253 | 95 | 158 (63) | 134 | 119 (47) | 74 | 179 (71) | |||
High | 47 | 17 | 30 (64) | 15 | 32 (68) | 15 | 32 (68) | |||
CDC25C | - | < 0.001 | < 0.001 | |||||||
Low | 112 | - | - - | 76 | 36 (32) | 47 | 65 (58) | |||
High | 188 | - | - - | 73 | 115 (61) | 42 | 146 (78) |