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Table 3 Time to breast cancer progression in relation to clinicopathological characteristics: Cox proportional hazards model

From: Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

Analysis

Overall survival

Metastasis-free survival

 

HR

95% CI

pvalue

HR

95% CI

pvalue

Univariate

      

Age

1.0074

0.9717 to 1.0444

0.6901

1.0134

0.9791 to 1.0490

0.4507

Stage

2.8065

1.1063 to 7.1200

0.0306

3.3893

1.4386 to 7.9850

0.0054

Grade

8.3473

1.1141 to 62.5437

0.0399

10.0599

1.3565 to 74.6075

0.0246

Tumour size

2.8301

1.0906 to 7.3445

0.0333

2.8825

1.1909 to 6.9770

0.0195

Lymph node

2.1072

0.9382 to 4.7326

0.0724

1.8045

0.8696 to 3.7445

0.1148

ERα

0.3322

0.1191 to 0.9265

0.0361

0.2413

0.0971 to 0.5992

0.0023

HER2

0.6813

0.3044 to 1.5247

0.3529

0.8075

0.4005 to 1.6280

0.5521

PR

0.727

0.3487 to 1.5159

0.3976

0.527

0.2614 to 1.0627

0.0749

Recurrence

2.0282

0.7885 to 5.2175

0.1444

1.7645

0.9107 to 3.4189

0.0940

Metastasis

7.824

2.7957 to 21.8962

< 0.0001

   

Death

   

2.4134

1.3737 to 4.2402

0.0022

Histological type

0.9002

0.2937 to 2.7597

0.8549

0.6848

0.2292 to 2.0455

0.4998

CXCL12 Island 4

4.1124

1.3539 to 12.4913

0.0130

11.5151

2.6886 to 49.3180

0.0010

CXCL12 Island 2

0.8083

0.2308 to 2.8313

0.7407

0.7528

0.2207 to 2.5676

0.6518

ESR1

3.2917

1.6312 to 6.6424

0.0009

3.1300

1.6632 to 5.8904

0.0004

Multivariate

      

Metastasis

5.2652

1.8200 to 15.2323

0.0022

   

ESR1

2.5752

0.9827 to 6.7484

0.0555

2.7569

1.0204 to 7.4486

0.0466

CXCL12 Island 4

*

7.1355

1.6480 to 30.8958

0.0089

ERα

*

0.3343

0.1247 to 0.8963

0.0302

Tumour size

*

1.9577

0.7137 to 5.3701

0.1942

  1. Abbreviations: HR, hazard ration; CI, confidence interval; SBR, Scarff-Bloom-Richardson classification; ERα, estrogen receptor alpha; PR, progesterone receptor; HER2, Human Epidermal growth factor Receptor-type 2. Statistical significance are in bold. * Variables that were not significant at Cox regression analysis.