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Table 1 Clinicopathological and molecular characteristics of CIMP subgroups.

From: Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

 

CIMP subgroup (n, %)

P

 

L

M

H

L vsM

M vsH

L vsH

 

19 (21)

13 (14)

59 (65)

   

Female

6 (32)

4 (31)

30 (51)

   

Male

13 (68)

9 (69)

29 (49)

0.952

0.211

0.175

Age ≥ 67 years

6 (32)

5 (38)

37 (63)

   

Age < 67 years

13 (68)

8 (62)

22 (37)

0.570

0.003

0.012

Proximal tumor site1

5 (26)

1 (8)

29 (49)

   

Distal tumor site2

14 (74)

12 (92)

29 (49)

0.152

< 0.001

0.001

ACPS Stage A or B

8 (42)

4 (31)

36 (61)

   

ACPS Stage C or D

11 (58)

9 (69)

23 (39)

0.520

0.025

0.105

LVI Negative

15 (79)

6 (46)

39 (66)

   

LVI Positive

4 (21)

7 (54)

20 (34)

0.049

0.188

0.126

EMVI Negative

19 (100)

8 (62)

52 (88)

   

EMVI Positive

0 (0)

5 (38)

7 (12)

0.005

0.031

0.024

PNI Negative

17 (89)

11 (85)

52 (88)

   

PNI Positive

2 (11)

2 (15)

7 (12)

0.744

0.506

0.708

TILS Negative3

9 (47)

5 (38)

26 (44)

   

TILS Positive

7 (37)

8 (62)

33 (56)

0.326

0.547

0.521

CIMPW - negative4

19 (100)

10 (77)

28 (47)

   

CIMPW - low

0 (0)

3 (23)

15 (25)

   

CIMPW - high

0 (0)

0 (0)

16 (27)

1.000

< 0.001

< 0.001

MSI+

2 (11)

0 (0)

13 (18)

   

MSI-

17 (89)

13 (100)

46 (78)

0.125

< 0.001

0.221

BRAF mutant

0 (0)

0 (0)

15 (25)

   

BRAF wildtype

19 (100)

13 (100)

44 (75)

1.000

< 0.001

< 0.001

KRAS mutant

3 (16)

0 (0)

26 (44)

   

KRAS wildtype

16 (84)

13 (100)

33 (56)

0.057

< 0.001

0.014

  1. L, CIMP-low; M, CIMP-mid; H, CIMP-high; LVI, lymphovascular invasion; EMVI, extramural vascular invasion; PNI, perineural invasion; TILS, tumour infiltrating lymphocytes; CIMPW, classification of CIMP using the Weisenberger et al panel, whereby CIMPW-high is defined as 3 or more methylated loci, CIMPW-low as 1 or 2 methylated loci and CIMPW-negative as no methylated loci. MSI, microsatellite instability; 1Tumor location was unknown for 1 patient in CIMP-H, 2Number of distal CRC that were located at rectal site were 13, 1 and 11 in CIMP-L, CIMP-M and CIMP-H respectively, 3TILS data unknown for 3 patients in CIMP-L, 4 P value for CIMPW was generated from comparison between CIMPW-high and CIMPW-low or CIMPW-negative.
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BMC Cancer

ISSN: 1471-2407

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