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Table 5 Associations of total antioxidant index and macronutrients with glioma survival†, stratified by histology group

From: Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma

Nutrient (unit) Tertiles

All or self-report (SR) only

Grade II

Grade III

Grade IV

 

Lower limit

 

Upper limit

 

(143 cases, 72 deaths)

(130 cases, 103 deaths)

(475 cases, 473 deaths)

     

HR

95% CI

HR

95% CI

HR

95% CI

Antioxidant index

       

T1:

50.1

to

1961.9

ALL

1

 

1

 

1

 

T2:

1963.2

to

3263.0

 

1.34

(0.70-2.54)

1.31

(0.78-2.18)

1.02

(0.78-1.32)

T3:

3266.1

to

13512.6

 

0.67

(0.30-1.47)

1.04

(0.58-1.88)

0.36*

(1.02-1.81)

T1:

50.1

to

1961.9

SR

1

 

1

 

1

 

T2:

1963.2

to

3263.0

 

1.41

(0.71-2.80)

1.36

(0.62-2.94)

1.18

(0.82-1.68)

T3:

3266.1

to

13512.6

 

0.74

(0.31-1.77)

1.03

(0.49-2.16)

1.07

(0.72-1.59)

Total Protein (g)

       

T1:

11.4

to

49.5

ALL

1

 

1

 

1

 

T2:

49.6

to

70.8

 

0.44*

(0.20-0.95)

1.44

(0.75-2.74)

1.08

(0.83-1.40)

T3:

71.1

to

241.5

 

0.32

(0.10-1.04)

1.73

(0.78-3.83)

0.64*

(0.43-0.95)

T1:

11.4

to

49.5

SR

1

 

1

 

1

 

T2:

49.6

to

70.8

 

0.40*

(0.18-0.93)

1.57

(0.74-3.31)

1.13

(0.78-1.62)

T3:

71.1

to

241.5

 

0.53

(0.15-1.81)

1.18

(0.42-3.27)

0.88

(0.52-1.50)

Total Fat (g)

       

T1:

10.2

to

47.1

ALL

1

 

1

 

1

 

T2:

47.2

to

72.7

 

1.33

(0.60-2.96)

0.77

(0.43-1.38)

1.13

(0.87-1.47)

T3:

72.9

to

213.0

 

0.88

(0.29-2.66)

0.73

(0.35-1.51)

1.10

(0.74-1.63)

T1:

10.2

to

47.1

SR

1

 

1

 

1

 

T2:

47.2

to

72.7

 

1.10

(0.47-2.54)

0.67

(0.29-1.53)

1.06

(0.73-1.53)

T3:

72.9

to

213.0

 

0.81

(0.26-2.53)

0.74

(0.30-1.85)

1.11

(0.61-2.01)

Total Cholesterol (mg)

       

T1:

17.2

to

166.1

ALL

1

 

1

 

1

 

T2:

166.2

to

272.7

 

0.53

(0.24-1.14)

0.86

(0.49-1.49)

1.50*

(1.17-1.93)

T3:

273.0

to

1322.0

 

0.76

(0.31-1.86)

0.49*

(0.25-0.95)

1.31

(0.97-1.78)

T1:

17.2

to

166.1

SR

1

 

1

 

1

 

T2:

166.2

to

272.7

 

0.59

(0.25-1.41)

1.04

(0.53-2.03)

1.39

(0.98-1.97)

T3:

273.0

to

1322.0

 

1.00

(0.38-2.59)

0.68

(0.28-1.63)

1.13

(0.71-1.80)

  1. † adjusted for reporting status (all cases vs self reported cases only), age at diagnosis (<48,48-65,>65), treatment (radiation, chemo, surgery - yes/no), education (<12, 12, >12), marital status (yes/no), total calories (continuous), pack years (median = 18.5), and age at first alcoholic drink (<18,18-20,>20).
  2. * p < 0.05
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