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Table 1 Pharmacokinetic parameters of 5-FU after the subcutaneous injection of 100 mg/kg of the free 5-FU drug and 5-FU-loaded PEG-hydrogel into SD rats.

From: Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel

Parameters

unit

5-FU

(n = 3, Mean ± SD)

5-FU-loaded PEG-hydrogel

(n = 3, Mean ± SD)

Vd/F

L

0.41 ± 0.04

10.60 ± 1.55

t1/2(a)

h

0.21 ± 0.06

0.06 ± 0.03

t1/2

h

0.15 ± 0.04

0.87 ± 0.17*

CLtot/F

l/h

2.04 ± 0.51

8.46 ± 1.07

Cmax

μg/ml

67.81 ± 15.84

7.47 ± 1.63

Tmax

h

0.25 ± 0.00

0.33 ± 0.14

AUC0-8 day

μg·h/ml

59.71 ± 10.58

14.14 ± 1.20

MRT

h

0.55 ± 0.03

8.03 ± 4.41*

  1. Vd/F; apparent volume of distribution, t1/2(a); absorption half life, t1/2; elimination half life, CLtot/F; total body clearance, Cmax; maximum serum concentration, Tmax; time to maximum concentration, AUC; area under the curve, MRT; mean residence time (AUMC/AUC). * 5-FU vs. 5-FU-loaded PEG-hydrogel (p < 0.05).
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BMC Cancer

ISSN: 1471-2407

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