Gene networks enriched with genes associated with S100A8. Gene networks of 1,015 genes that highly correlated with S100A8. Up- and down-regulated genes in the high S100A8 cluster (HSC) group are indicated in red and green, respectively. The intensity of color is indicative of the degree of over- or under-expression. Genes without highlighted color are not part of the progression signature but are associated with the regulated genes. Each line and arrow represents functional and physical interactions between the genes and the direction of regulation reported in the literature.