Figure 6
From: Differential CARM1 expression in prostate and colorectal cancers
In vivo association of CARM1 in p53 and NF-κB mediated signals. Caco-2 colon cancer cells were also transfected with either p53-luc (A) or NF-κB-luc (B) with pSG-CARM1. CARM1 interacts in vivo with the promoters of p21 and cyclin D1 (CCND1). C, chromatin immunoprecipitation from caco-2 colon cancer cells using antibodies against p53, CARM1, and IgG. D, cells were grown in the presence of TNFα for 30 minutes and precipitated with antibodies against p65, CARM1, or normal IgG.