Table 3 Molecular pathways discriminating chRCC and oncocytoma.

280

0

6.206

4

17

44

Valine, leucine and isoleucine degradation

640

0

6.349

3

13

33

Propanoate metabolism

190

0

3.093

11

27

114

Oxidative phosphorylation

970

0

4.488

4

12

38

Aminoacyl-tRNA biosynthesis

20

0.001

4.833

3

9

27

Citrate cycle (TCA cycle)

330

0.001

4.032

3

10

34

Arginine and proline metabolism

4120

0.003

3.13

4

11

45

Ubiquitin mediated proteolysis

Pathways relatively upregulated in chRCC

KEGGID

Pvalue

OddsRatio

ExpCount

Count

Size

Term

4660

0

3.263

9

23

93

T cell receptor signaling pathway

4662

0

3.945

6

18

63

B cell receptor signaling pathway

4514

0

2.505

12

26

129

Cell adhesion molecules (CAMs)

4670

0

2.676

10

23

108

Leukocyte transendothelial migration

5220

0

3.05

7

18

76

Chronic myeloid leukemia

5212

0

2.977

7

17

73

Pancreatic cancer

4520

0.001

2.823

7

17

76

Adherens junction

5130

0.001

3.335

5

13

51

Pathogenic Escherichia coli infection - EHEC

5131

0.001

3.335

5

13

51

Pathogenic Escherichia coli infection - EPEC

4530

0.001

2.277

11

22

117

Tight junction

4664

0.001

2.65

7

16

75

Fc epsilon RI signaling pathway

4620

0.003

2.268

10

19

101

Toll-like receptor signaling pathway

4012

0.003

2.372

8

17

87

ErbB signaling pathway

564

0.003

2.621

6

14

66

Glycerophospholipid metabolism

4150

0.004

2.964

4

11

47

mTOR signaling pathway

5120

0.004

2.523

6

14

68

Epithelial cell signaling in Helicobacter pylori infection

4210

0.005

2.293

8

16

84

Apoptosis

4070

0.006

2.317

7

15

78

Phosphatidylinositol signaling system

4540

0.007

2.124

9

17

95

Gap junction

4912

0.009

2.07

9

17

97

GnRH signaling pathway

5221

0.01

2.536

5

11

53

Acute myeloid leukemia