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Table 5 Risk of esophageal cancer associated with HPV infection according to gender, age, tobacco and alcohol use, and tumor stage

From: Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study

   HPV(-)
No.(%)
HPV(+)
No.(%)
Unadjusted
OR (95% CI)
Adjusted
OR (95% CI)*
Age ≤60 121(63.4) 141(57.8) 1.00   1.00  
  > 60 70(36.6) 103(42.2) 1.26 (0.86-1.86) 1.17 (0.78-1.75)
Gender Female 63(33.0) 65(26.6) 1.00   1.00  
  Male 128(67.0) 179(73.4) 1.36 (0.90-2.05) 1.06 (0.64-1.75)
Tobacco† No 104(55.3) 111(45.7) 1.00   1.00  
  Yes 84(44.7) 132(54.3) 1.47‡ (1.00-2.16) 1.08 (0.64-1.80)
Alcohol†† No 143(76.5) 151(62.9) 1.00   1.00  
  Yes 44(23.5) 89(37.1) 1.92‡‡ (1.25-2.94) 1.69‡ (1.01-2.83)
TNM stage I 20(10.5) 39(16.0) 1.00   1.00  
  IIa 77(40.3) 95(38.9) 0.63 (0.34-1.17) 0.68 (0.36-1.28)
  IIb 59(30.9) 59(24.2) 0.51 (0.27-0.98) 0.58 (0.30-1.14)
  III 35(18.3) 51(20.9) 0.75 (0.38-1.49) 0.74 (0.36-1.50)
  1. *Age, gender, smoking, tobacco use, alcohol use and TNM stage were included in the multivariate logistic regression model.
  2. †Information on tobacco was missing in four cases.
  3. ††Information on alcohol was missing in eight cases.
  4. ‡P<0.05.
  5. ‡‡P<0.01.