Table 1 Demographic characteristics and TNM stage of subjects by region and HPV infection status
| Â | Â | Region | HPV infection status | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | China | Â | Â | Total (N = 435) | Â | ||||
Variables |  | P †|  |  | P ††|  |  |  |  | |
| Â | Â | Anyang N = 166 No.(%) | Shantou N = 103 No.(%) | Xinjiang N = 78 No.(%) | Total N = 347 No.(%) | US N = 88 No.(%) | Â | HPV(-) No.(%) | HPV(+) No.(%) | Â |
Age | ≤60 | 87(52.4) | 74(71.8) | 62(79.5) | 223(64.3) | 39(44.3) | 0.001 | 121(63.4) | 141(57.8) | 0.239 |
| Â | >60 | 79(47.6) | 29(28.2) | 16(20.5) | 124(35.7) | 49(55.7) | Â | 70(36.6) | 103(42.2) | Â |
Gender | Female | 55(33.1) | 34(33.0) | 27(34.6) | 116(33.4) | 12(13.6) | <0.001 | 63(33.0) | 65(26.6) | 0.150 |
| Â | Male | 111(66.9) | 69(67.0) | 51(65.4) | 231(66.6) | 76(86.4) | Â | 128(67.0) | 179(73.4) | Â |
Tobacco‡ | Never | 83(50.6) | 54(52.4) | 59(75.6) | 196(56.8) | 19(22.1) | <0.001 | 104(55.3) | 111(45.7) | 0.047 |
| Â | Ever | 81(49.4) | 49(47.6) | 19(24.4) | 149(43.2) | 67(77.9) | Â | 84(44.7) | 132(54.3) | Â |
Alcohol‡‡ | Never | 118(72.0) | 91(88.3) | 65(83.3) | 274(79.4) | 20(24.4) | <0.001 | 143(76.5) | 151(62.9) | 0.003 |
| Â | Ever | 46(28.0) | 12(11.7) | 13(16.7) | 71(20.6) | 62(75.6) | Â | 44(23.5) | 89(37.1) | Â |
Race | Han | 166(100.0) | 103(100.0) | - | 269(77.5) | - | - | 121(63.4) | 148(60.7) | 0.257 |
| Â | Kazakh | - | - | 78(100.0) | 78(22.5) | - | Â | 36(18.8) | 42(17.2) | Â |
| Â | Caucasion | - | - | - | - | 41(46.6) | Â | 18(9.4) | 23(9.4) | Â |
| Â | Black | - | - | - | - | 8(9.1) | Â | 5(2.6) | 3(1.2) | Â |
| Â | Japanese | - | - | - | - | 39(44.3) | Â | 11(5.8) | 28(11.5) | Â |
Anatomic location* | Upper third | 20(18.3) | - | 1(1.6) | - | - | - | 14(17.9) | 7(7.5) | 0.115 |
| Â | Middle third | 71(65.1) | - | 33(53.2) | - | - | Â | 45(57.7) | 59(63.4) | Â |
| Â | Lower third | 18(16.5) | - | 28(45.2) | - | - | Â | 19(24.4) | 27(29.0) | Â |
TNM stage | I | 7(4.2) | 21(20.4) | 0(0.0) | 28(8.1) | 31(35.2) | <0.001 | 20(10.5) | 39(16.0) | 0.204 |
| Â | IIa | 84(50.6) | 26(25.2) | 34(43.6) | 144(41.5) | 28(31.8) | Â | 77(40.3) | 95(38.9) | Â |
| Â | IIb | 35(21.1) | 37(36.0) | 34(43.6) | 106(30.5) | 12(13.7) | Â | 59(30.9) | 59(24.2) | Â |
| Â | III | 40(24.1) | 19(18.4) | 10(12.8) | 69(19.9) | 17(19.3) | Â | 35(18.3) | 51(20.9) | Â |