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Table 1 Demographic characteristics and TNM stage of subjects by region and HPV infection status

From: Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study

   Region HPV infection status
   China    Total (N = 435)  
Variables   P †    P ††     
   Anyang
N = 166
No.(%)
Shantou
N = 103
No.(%)
Xinjiang
N = 78
No.(%)
Total
N = 347
No.(%)
US
N = 88
No.(%)
  HPV(-)
No.(%)
HPV(+)
No.(%)
 
Age ≤60 87(52.4) 74(71.8) 62(79.5) 223(64.3) 39(44.3) 0.001 121(63.4) 141(57.8) 0.239
  >60 79(47.6) 29(28.2) 16(20.5) 124(35.7) 49(55.7)   70(36.6) 103(42.2)  
Gender Female 55(33.1) 34(33.0) 27(34.6) 116(33.4) 12(13.6) <0.001 63(33.0) 65(26.6) 0.150
  Male 111(66.9) 69(67.0) 51(65.4) 231(66.6) 76(86.4)   128(67.0) 179(73.4)  
Tobacco‡ Never 83(50.6) 54(52.4) 59(75.6) 196(56.8) 19(22.1) <0.001 104(55.3) 111(45.7) 0.047
  Ever 81(49.4) 49(47.6) 19(24.4) 149(43.2) 67(77.9)   84(44.7) 132(54.3)  
Alcohol‡‡ Never 118(72.0) 91(88.3) 65(83.3) 274(79.4) 20(24.4) <0.001 143(76.5) 151(62.9) 0.003
  Ever 46(28.0) 12(11.7) 13(16.7) 71(20.6) 62(75.6)   44(23.5) 89(37.1)  
Race Han 166(100.0) 103(100.0) - 269(77.5) - - 121(63.4) 148(60.7) 0.257
  Kazakh - - 78(100.0) 78(22.5) -   36(18.8) 42(17.2)  
  Caucasion - - - - 41(46.6)   18(9.4) 23(9.4)  
  Black - - - - 8(9.1)   5(2.6) 3(1.2)  
  Japanese - - - - 39(44.3)   11(5.8) 28(11.5)  
Anatomic location* Upper third 20(18.3) - 1(1.6) - - - 14(17.9) 7(7.5) 0.115
  Middle third 71(65.1) - 33(53.2) - -   45(57.7) 59(63.4)  
  Lower third 18(16.5) - 28(45.2) - -   19(24.4) 27(29.0)  
TNM stage I 7(4.2) 21(20.4) 0(0.0) 28(8.1) 31(35.2) <0.001 20(10.5) 39(16.0) 0.204
  IIa 84(50.6) 26(25.2) 34(43.6) 144(41.5) 28(31.8)   77(40.3) 95(38.9)  
  IIb 35(21.1) 37(36.0) 34(43.6) 106(30.5) 12(13.7)   59(30.9) 59(24.2)  
  III 40(24.1) 19(18.4) 10(12.8) 69(19.9) 17(19.3)   35(18.3) 51(20.9)  
  1. †P values for the differences between China and US were calculated with the Pearson Chi-square test.
  2. ††P values for the differences between HPV(+) and HPV(-) groups were calculated with the Pearson Chi-square test.
  3. ‡Tobacco was classified as any record of use (ever) or no record of use (never). Information on tobacco was missing in four cases.
  4. ‡‡Alchol was classified as any record of use (ever) or no record of use (never). Information on tobacco was missing in eight cases.
  5. *Part of the data was not available, and statistic analyses were based on available data.