Table 2 Correlation of IGFIR, VEGF and VEGF-C Expression with Clinicopathologic Features in Colorectal Tumor.
Clinicopathologic parameters | Case No. | IGFIR expression | P value | VEGF expression | P value | VEGF-C expression | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Low | High | Â | Low | High | Â | Low | High | Â |
Total cases | 98 | 53 (54%) | 45 (46%) | Â | 46 (47%) | 52 (53%) | Â | 53 (54%) | 45 (46%) | Â |
Age | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   ≤50 | 25 | 14 (56%) | 11 (44%) | 0.824 | 11 (44) | 14 (56%) | 0.733 | 14 (56%) | 11 (44%) | 0.351 |
   >50 | 73 | 39 (53%) | 34 (47%) |  | 35 (45%) | 38 (55%) |  | 33 (45%) | 40 (55%) |  |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Male | 55 | 29 (53%) | 26 (47%) | 0.761 | 24 (44%) | 31 (56%) | 0.459 | 28 (51%) | 27 (49%) | 0.509 |
   Female | 43 | 24 (56%) | 19 (44%) |  | 22 (51%) | 21 (49%) |  | 19 (44%) | 24 (56%) |  |
Tumor position | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Colon | 44 | 20 (45%) | 24 (55%) | 0.122 | 19 (43%) | 25 (57%) | 0.501 | 23 (52%) | 21 (48%) | 0.440 |
   Rectum | 54 | 33 (61%) | 21 (39%) |  | 27 (50%) | 27 (50%) |  | 24 (44%) | 30 (56%) |  |
Infiltration location | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Submucosa | 30 | 19 (63%) | 11 (37%) | 0.109 | 17 (57%) | 13 (43%) | 0.180 | 15 (50%) | 15 (50%) | 0.052 |
   Muscularis propria | 6 | 1 (17%) | 5 (83%) |  | 1 (17%) | 5 (83%) |  | 0 (0%) | 6 (100%) |  |
   Outer layer | 62 | 33 (53%) | 29 (47%) |  | 28 (45%) | 34 (55%) |  | 32 (52%) | 30 (48%) |  |
TNM stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   I | 24 | 18 (75%) | 6 (25%) | < 0.001 | 16 (67%) | 8 (33%) | 0.001 | 13 (54%) | 11 (46%) | 0.006 |
   II | 32 | 23 (72%) | 9 (28%) |  | 20 (63%) | 12 (37%) |  | 22 (69%) | 10 (31%) |  |
   III | 36 | 10 (28%) | 26 (72%) |  | 8 (22%) | 28 (78%) |  | 10 (28%) | 26 (72%) |  |
   IV | 6 | 2 (33%) | 4 (67%) |  | 2 (33%) | 4 (67%) |  | 2 (33%) | 4 (67%) |  |
Histologic differentiation | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Poor | 30 | 6 (20%) | 24 (80%) | < 0.001 | 7 (23%) | 23 (77%) | 0.007 | 5 (17%) | 25 (63%) | < 0.001 |
   Moderate | 44 | 30 (68%) | 14 (32%) |  | 24 (55%) | 20 (45%) |  | 24 (55%) | 20 (45%) |  |
   Good | 24 | 17 (71%) | 7 (29%) |  | 15 (63%) | 9 (37%) |  | 18 (75%) | 6 (25%) |  |
Vascular invasion | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 49 | 34 (69%) | 15 (31%) | 0.002 | 34 (69%) | 15 (31%) | < 0.001 | 32 (65%) | 17 (35%) | 0.001 |
   Positive | 49 | 19 (39%) | 30 (61%) |  | 12 (24%) | 37 (76%) |  | 15 (31%) | 34 (69%) |  |
Lymph node metastasis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 50 | 36 (72%) | 14 (28%) | < 0.001 | 30 (60%) | 20 (40%) | 0.008 | 32 (64%) | 18 (36%) | 0.001 |
   Positive | 48 | 17 (35%) | 31 (65%) |  | 16 (33%) | 32 (67%) |  | 15 (31%) | 33 (69%) |  |