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Table 3 Percentages of patients showing positive immunohistochemical reactions to p-ELK-1, ATF-2 [31], p50 and p65 [5] in normal prostate (NP), benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and average optical densities of immunostaining in positive patients.

From: Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

 

p-ELK-1

p-ATF-2

p50

p65

Prostates (no.)

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Normal (20)

100

2.41 ± 0.9a

100

3.34 ± 0.83a

60

7.88 ± 2.4*

0

 

BPH (35)

        

   Cytoplasm

14.28

9.42 ± 5.13*

  

100

18.6 ± 1.72#

71.4

9.08 ± 3.23*

   Nucleus

82.85

10.52 ± 2.56b

45.71

5.25 ± 2.16a

    

PIN

        

   Low grade PIN (12)

100

3.22 ± 0.7a

100

4.32 ± 1.09*

58.3

15.32 ± 2.00#

0

 

   High grade PIN (15)

        

Cytoplasm

60

17.35 ± 1.45#

53.3

13.35 ± 1.78#

86.6

27.51 ± 2.79§

93.3

30.17 ± 3.08#

Nucleus

40

18.27 ± 2.31c

26.6

12.31 ± 4.21b

26.6

28.76 ± 3.31a

13.3

29.77 ± 2.13a

PC

        

   Low Gleason (21)

        

Cytoplasm

66.6

19.62 ± 5.64#

61.9

12.68 ± 3.28#

80.9

28.01 ± 2.25§

100

23.8 ± 2.93§

Nucleus

42.85

18.65 ± 3.4c

23.8

10.58 ± 1.2b

30.1

32.08 ± 2.96a

19

28.34 ± 2.04a

   Medium Gleason (51)

        

Cytoplasm

72.54

17.75 ± 4.54#

68.62

11.75 ± 3.45#

94.1

29.17 ± 1.22§

92.1

29.09 ± 1.90#

Nucleus

37.25

17.23 ± 3.56c

19.6

9.56 ± 3.87b

41.2

33.82 ± 4.07a

45.1

34.91 ± 4.32b

   High Gleason (21)

        

Cytoplasm

85.71

19.76 ± 4.78#

76.19

12.98 ± 5.11#

100

39.37 ± 4.15¥

80.9

36.71 ± 2.18¥

Nucleus

33.3

18.76 ± 3.87c

14.28

13.43 ± 3.56b

47.6

41.26 ± 2.31b

71.4

46.56 ± 1.20c

  1. Average optical densities were evaluated only in patients showing positive immunoreactions. Statistical analysis refers to each antibody separately. Statistical analysis also separated cytoplasmic (symbol superscripts) and nuclear (letter superscripts) values. Values denoted by different superscripts are significantly different from each other. Significance was determined by the one way ANOVA test at p ≤ 0.05, by multiple pairwise comparisons (GraphPad PRISMA 3.0 computer program).