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Table 1 Percentages of patients showing positive immunohistochemical reactions to c-IAP-2, c-IAP-1/2 and ILP in normal prostate (NP), benign prostatic hyperplasia (BPH), prostatic carcinoma (PC) and average optical densities of immunostaining in positive patients.

From: Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

 

c-IAP-1/2

c-IAP-2

ILP

Prostates (no.)

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Positive cases (%)

Optical density

Normal (20)

80

19.64 ± 1.06

60

8.94 ± 0.61a

20

5.39 ± 1.18a

BPH (33)

57.57

18.36 ± 3.29

57.57

14.30 ± 1.2b

66.6

17.91 ± 1.44b

PIN

      

   Low grade PIN (12)

58.37

18.04 ± 1.29

66.6

9.83 ± 0.9a

66.6

7.26 ± 1.01a

   High grade PIN (15)

60

18.91 ± 1.69

46.6

15.33 ± 1.52b

80

23.14 ± 1.49c

PC

      

   Low Gleason (23)

60.86

19.12 ± 1.63

39.13

14.44 ± 1.56b

82.6

23.87 ± 1.85c

   Medium Gleason (51)

70.58

18.36 ± 2.38

39.21

19.08 ± 2.16c

82.35

23.79 ± 2.11c

   High Gleason (21)

57.14

18.07 ± 1.94

42.85

18.45 ± 1.75c

100

27.78 ± 1.91d

  1. Average optical densities were evaluated only in patients showing positive immunoreactions. Statistical analysis refers to each antibody separately. Values denoted by different superscripts are significantly different from each other. Significance was determined by the one way ANOVA test at p ≤ 0.05, by multiple pairwise comparisons (GraphPad PRISMA 3.0 computer program).