Figure 6
SR/CR leukocyte migration and cancer destruction. A proposed model for SR/CR mediated cancer cell killing. S180 secretes chemotactic factors that attract SR/CR leukocytes (SR) to the site of the cancer, allowing tight contact between the leukocytes and cancer cells to be made which facilitates tumor destruction. LL/2 and MethA produce little or no chemoattractant and are, therefore, not efficiently killed by SR/CR leukocytes. Co-injection of MethA or LL/2 with S180 results in attraction of SR/CR leukocytes to the site of the cancer and efficient cell killing of these cancer cell lines. This suggests that some cancer cells may escape from SR/CR resistance because they do not induce SR/CR leukocyte infiltration and demonstrates the importance of leukocyte infiltration in the SR/CR resistance mechanism.