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Table 4 SOCS 4 - 7 Mean mRNA expression levels

From: Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer

Patient and tumour characteristics SOCS4 Mean (SD) P SOCS5 Mean (SD) P SOCS6 Mean (SD) P SOCS7 Mean (SD) P
ER Status
   ER(-) vs. ER(+) 198 (834) vs. 296 (1035) 0.63 1669 (2950) vs. 1066 (2215) 0.25 450 (1209) vs. 2018 (5905) 0.13 2310 (8080) vs. 715 (1341) 0.11
Tumor Grade
   Grade 1 vs. 2 142 (540) vs. 554 (1468) 0.13 834 (2468) vs. 2164 (3270) 0.09 2110 (7427) vs. 968 (2171) 0.51 5459 (14250) vs. 1396 (2583) 0.22
   Grade 1 vs. 3 142 (540) vs. 113 (380) 0.82 834 (2468) vs. 2076 (5191) 0.17 2110 (7427) vs. 475 (1267) 0.34 5459 (14250) 0.13
   Grade 2 vs. 3 554 (1468) vs. 113 (380) 0.07 2164 (3270) vs. 2076 (5191) 0.92 968 (2171) vs. 475 (1267) 0.21 vs. 427 (1339) 1396 (2583) vs. 427 (1339) 0.037
NPI
   NPI 1 vs. 2 276 (1004) vs. 168 (513) 0.49 1742(2846) vs. 1715 (3064) 0.97 1117 (4564) vs. 687 (1610) 0.51 2740 (8754) vs. 518 (1189) 0.06
   NPI 1 vs. 3 276 (1004) vs. 419 (1441) 0.72 1742 (2846) vs. 3132 (9006) 0.56 117 (4564) vs. 439 (1138) 0.31 2740 (8754) vs. 538 (1125) 0.07
   NPI 2 vs. 3 168 (513) vs. 419 (1441) 0.52 1715 (3064) vs. 3132 ( 9006) 0.56 687 (1610) vs. 439 (1138) 0.53 518 (1189) vs. 538 (1125) 0.95
TNM
   TNM 1 vs. 2 384 (1208) vs. 180 (532) 0.25 1856 (3095) vs. 2328 (6035) 0.66 552 (1217) vs. 1925 (5786) 0.16 2239 (7923) vs. 1329 (4566) 0.47
   TNM 1 vs. 3 384(1208) vs. 75 (198) 0.08 1856 (3095) vs. 1521(3114) 0.8 552 (1217) vs. 93 (217) 0.01 2239 (7923) vs. 137 (353) 0.04
   TNM 1 vs. 4 384 (1208) vs. 1.5 (3) 0.02 1856 (3095) vs. 0.26 (0.53) 0.00 552 (1217) vs. 156 (33.7) 0.001 2239 (7923) vs. 0.004 (0.008) 0.03
   TNM 2 vs. 3 180 (532) vs. 75 (198) 0.37 2328 (6035) vs. 1521 (3114) 0.61 1925 (5786) vs. 93 (217) 0.06 1329 (4566) vs. 137 (353) 0.13
   TNM 2 vs. 4 180 (532) vs. 1.5 (3) 0.049 2328 (6035) vs. 0.26( 0.53) 0.03 1925 (5786) vs. 22.8 (33.7) 0.05 1329 (4566) vs. 0.004 (0.008) 0.09
   TNM 3 vs. 4 75 (198) vs. 1.5 (3) 0.36 1521 (3114) vs. 0.26 (0.53) 0.24 93 (217) vs. 22.8 (33.7) 0.43 137 (353) vs. 0.004 (0.008) 0.35
Survival
   DF vs. LR 146 (566) vs. 959 (2223) 0.37 1551 (2851) vs. 1807 (2315) 0.79 994 (3987) vs. 776 (1311) 0.75 2110 (7490) vs. 271 (716) 0.04
   DF vs. DR 146 (566) vs. 2.1 (3.3) 0.024 1551 (2851) vs. 10190 (14338) 0.25 994 (3987) vs. 372 (582) 0.23 2110 (7490) vs. 246 (500) 0.03
   DF vs. D 146 (566) vs. 685 (1577) 0.23 1551 (2851) vs. 1190 (2787) 0.66 994 (3987) vs. 825 (1967) 0.81 2110 (7490) vs. 467 (1232) 0.07
  1. SOCS 4 - 7 Mean mRNA expression levels in a cohort of 128 breast cancer patients; a comparison between subgroups with different tumour grade, NPI score, and TNM stage. SD: Standard deviation, DF: Disease free survival, LR: Local disease recurrence, DR: Distant disease recurrence, D: Death from breast cancer