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Table 3 SOCS 1 - 3 Mean mRNA expression levels

From: Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer

Patient and tumour characteristics SOCS1 Mean (SD) P SOCS2 Mean (SD) P SOCS3 Mean (SD) P
ER Status
   ER(-) vs. ER(+) 47(165) vs. 18.4(38.4) 0.18 329585 (1361524) vs. 241896 (1097499) 0.72 0.6 (3.1) vs. 3.2 (10.7) 0.16
Tumor Grade
   Grade 1 vs. 2 90(189) vs. 41(163) 0.33 335817 (1426927) vs. 44859 (128040) 0.37 4 (13.5) vs. 0.8 (4.1) 0.32
   Grade 1 vs. 3 90(189) vs. 10.3(53.6) 0.08 335817 (1426927) vs. 512760 (1654661) 0.65 4 (13.5) vs. 0.7 (3.1) 0.3
   Grade 2 vs. 3 41(163) vs. 10.3(53.6) 0.26 44859 (128040) vs. 512760 (1654661) 0.04 0.8(4.1) vs. 0.7 (3.1) 0.9
NPI
   NPI 1 vs. 2 20.1(86.4) vs. 51(178) 0.32 495133 (1685902) vs. 66274 (241181) 0.06 1.2 (7.7) vs. 2.1 (6) 0.52
   NPI 1 vs. 3 20.1(86.4) vs. 58(148) 0.35 495133 (1685902) vs. 12414 (25254) 0.03 1.2 (7.7) vs. 0.1 (0.2) 0.26
   NPI 2 vs. 3 51(178) vs. 58(148) 0.88 66274 (241181) vs. 12414 (25254) 0.18 2.1 (6) vs. 0.1 (0.2) 0.04
TNM
   TNM 1 vs. 2 53(170) vs. 20.5(67.1) 0.19 157325 (679157) vs. 364680 (1454925) 0.42 1.9 (8.4) vs. 0.9 (3.6) 0.79
   TNM 1 vs. 3 53(170) vs. 5.7(13) 0.039 157325 (679157) vs. 1180151 (3122352) 0.42 1.9 (8.4) vs. 0.3 (0.9) 0.17
   TNM 1 vs. 4 53(170) vs. 3.2(5.3) 0.027 157325 (679157) vs. 3256 (6508) 0.08 1.9 (8.4) vs. 0.2 (0.2) 0.12
   TNM 2 vs. 3 20.5(67) vs. 5.7(13) 0.23 364680 (1454925) vs. 1180151 (3122352) 0.52 0.9 (3.6) vs. 0.3 (0.9) 0.39
   TNM 2 vs. 4 20.5(67) vs. 3.2(5.3) 0.13 364680 (1454925) vs. 3256 (6508) 0.14 0.9(3.6) vs. 0.2 (0.2) 0.23
   TNM 3 vs. 4 5.7(13) vs. 3.2(5.3) 0.67 1180151(3122352) vs. 3256 (6508) 0.36 0.3(0.9) vs. 0.2 (0.2) 0.68
Survival
   DF vs. LR 48(154) vs. 1.2(3.2) 0.007 360706 (1370000) vs. 3499 (9061) 0.02 1.5 (7.3) vs. 0.8 (2.1) 0.55
   DF vs. DR - - 360706 (1370000) vs. 3897(8714) 0.02 - -
   DF vs. D 48(154) vs. 7.4(13.3) 0.02 360706 (1370000) vs. 27239 (81017) 0.03 1.5 (7.3) vs. 0.4 (1.1) 0.22
  1. SOCS 1 - 3 Mean mRNA expression levels in a cohort of 128 breast cancer patients; a comparison between subgroups with different tumour grade, NPI score, and TNM stage. SD: Standard deviation, DF: Disease free survival, LR: Local disease recurrence, DR: Distant disease recurrence, D: Death from breast cancer