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Figure 8 | BMC Cancer

Figure 8

From: Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid

Figure 8

THL inhibits the growth of human MDA-MB-231 breast cancer xenografts in SCID mice. Effect of THL on the body weight A), tumor growth B), final tumor size C), and final tumor weight D) of NOD-SCID mice subcutaneously inoculated with human MDA-MB-231 breast cancer cells. For body weight, values represent means ± SD, n = 4 - 5 mice per group. For tumor volume data, values represent means ± SD, n = 8 - 10 tumors per group. For tumor weight data, values represent means ± SD, n = 6 tumors per group. **P < 0.001 versus PBS-treated mice. E) THL inhibits the angiogenesis of MDA-MB-231 tumors grown in NOD-SCID mice. Upper panel, images of CD31-positive stained microvessels in tumor sections of PBS- and THL-treated mice. Lower panel, quantitation of microvessels in tumor sections of PBS- and THL-treated mice. For each section, 4-6 randomly chosen fields were counted. Values represent means ± SD, n = 6 tumors per group. **P < 0.001 versus PBS-treated mice. F) THL induces the apoptosis of MDA-MB-231 tumors grown in NOD-SCID mice. Upper panel, images of TUNEL and Hoechst 33258 staining of tumor sections from PBS- and THL-treated mice. Lower panel, quantitation of TUNEL-positive cells in tumor sections of PBS- and THL-treated mice. For each section, 4-6 randomly chosen fields were counted. Values represent means ± SD, n = 6 tumors per group. *P < 0.05 versus PBS-treated mice.

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