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Figure 6 | BMC Cancer

Figure 6

From: Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade

Figure 6

RhoA/ROCK-2/moesin cascade was involved in VEGF-C-enhanced cell migration and invasion. (A-B) Cells were treated with VEGF-C (100 ng/mL) for 48 h after transfection with scrambled siRNA, moesin siRNA or ROCK-2 siRNA. The upper black lines indicate the starting line and the lower black lines indicate the mean migration distance. Cell migration was assayed and the migration cell numbers from the starting line are expressed as mean ± SD. ** = P < 0.01 vs. scrambled siRNA control; ## = P < 0.01 vs. VEGF-C in scrambled siRNA group. (C) Cells were treated with VEGF-C (100 ng/mL) for 48 h after transfection with scrambled siRNA, moesin siRNA or ROCK-2 siRNA. Cell invasion was assayed using invasion chambers and invasion indexes were shown. The experiments were performed in triplicates. ** = P < 0.01 vs. scrambled siRNA control; ## = P < 0.01 vs. VEGF-C in scrambled siRNA group.

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