Figure 5

ROCK-2 silencing blocked VEGF-C effect on moesin activation. (A-B) Cells were exposed to VEGF-C (100 ng/mL) after transfection with 100 nM target siRNA for ROCK-2 or scrambled siRNA for 48 h. Cell contents of wild-type or phosphorylated moesin are shown ** = P < 0.01 vs. corresponding scrambled siRNA control; ## = P < 0.01 vs VEGF-C in scrambled siRNA group; †† = P < 0.01 vs. ROCK-2 in scrambled siRNA control. The experiment was performed in triplicates and representative images are shown.