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Table 1 Cox regression analysis for various potential prognostic factors in survival

From: Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer

   

Overall survival in all patients

   

Disease-free survival in N0 M0 patients at nephroureterectomy

 

Variable

Unfavorable/favorable characteristics

No. of Patients

Analysis

Relative

risk

95% confidential

interval

P value

No. of Patients

Analysis

Relative

risk

95% confidential

interval

P value

   

Univariate (U)

2.626

1.486 - 4.641

0.0009

 

Univariate (U)

1.947

1.117-3.392

0.0187

Grade

3/2/1

44/54/10

    

32/51/9

    
   

Multivariate (M)

1.008

0.488 - 2.083

0.6126

 

Multivariate (M)

1.047

0.427 - 1.678

0.6332

   

U

3.138

2.065 - 4.768

< 0.0001

 

U

1.905

1.308 - 2.774

0.0008

pT

4/3/2/1 >

8/41/31/28

    

3/37/26/26

    
   

M

1.499

0.837 - 2.526

0.1454

 

M

1.291

0.479 - 1/302

0.3551

   

U

3.049

2.005 - 4.636

< 0.0001

     

pN

(+)/(-)

16/92

         
   

M

1.48

0.894 - 2.448

0.1271

     
   

U

11.024

5.550 - 21.896

< 0.0001

 

U

10.298

4.737 - 22.388

< 0.0001

LVI

(+)/(-)

56/52

    

40/52

    
   

M

6.923

2432 - 19.707

< 0.0001

 

M

9.954

4.093 - 24.204

< 0.0001

   

U

4.363

2.188 - 8.702

< 0.0001

 

U

2.917

1.494 - 5.694

0.0017

Rac1

high/low

46/62

    

33/59

    
   

M

1.87

0.863 - 4.094

0.1223

 

M

1.323

0.627 - 2.791

0.4621

   

U

12.633

4.869 - 32.776

< 0.0001

 

U

4.814

2.384 - 9.721

< 0.0001

Pak1

high/low

49/59

    

35/57

    
   

M

3.635

1.230 - 10.741

0.0196

 

M

3.526

1.564 - 7.946

0.0024