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Figure 2 | BMC Cancer

Figure 2

From: Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivity

Figure 2

Detection of total CD44, by monoclonal antibody in PC-3M cells. The appearance of a predominant cleavage product at 75 kD (lane 1) rather than a higher molecular weight form, is expected based on our experience [1–4, 14]. Re-expression of CD44s as a Fusion protein with luciferase produced a 137 kD form, with some residual 75-kD form, probably cleaved off after trypsinizing. The forced expression of CD44's intracellular binding partner merlin potentiated the increased CD44s (lane 5).

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BMC Cancer

ISSN: 1471-2407

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